SMAD6

SMAD family member 6
OMIM: 602931, Gene2Phenotype

9 panels

Panel Reviews Mode of inheritance Details
9 panels
Green SMAD6 in Limb disorders


Level 2: Musculoskeletal
Version 7.20
Latest signed off version: v7.0 (30 Apr 2025)

Component of the following Super Panels:

  • Paediatric disorders
  • review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • Expert list
    Phenotypes
    • radioulnar synostosis
    Red SMAD6 in Familial non syndromic congenital heart disease

    Level 3: Congenital heart disease
    Level 2: Cardiovascular disorders
    Version 1.90

    review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • Literature
    • Radboud University Medical Center, Nijmegen
    Phenotypes
    • Aortic valve disease 2, 614823
    Red SMAD6 in Thoracic aortic aneurysm or dissection (GMS)


    Level 2: Cardiology
    Version 4.5
    Latest signed off version: v4.0 (30 Apr 2025)

    review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Red
    • NHS GMS
    • London South GLH
    • London South GLH
    Phenotypes
    • Aortic valve disease 2 614823
    Red SMAD6 in Thoracic aortic aneurysm or dissection

    Level 3: Connective tissue disorders and aortopathies
    Level 2: Cardiovascular disorders
    Version 1.129

    review Not set
    Sources
    • London South GLH
    Green SMAD6 in Skeletal dysplasia


    Level 2: Musculoskeletal
    Version 8.34
    Latest signed off version: v8.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Paediatric disorders
  • review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • NHS GMS
    Phenotypes
    • {Radioulnar synostosis, nonsyndromic}, OMIM:179300
    Red SMAD6 in Fetal anomalies


    Level 2: Fetal (including NIPD)
    Version 6.140
    Latest signed off version: v6.0 (30 Apr 2025)

    review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • NHS GMS
    Phenotypes
    • {Craniosynostosis 7, susceptibility to}, OMIM:617439
    • Aortic valve disease 2, OMIM:614823
    • {Radioulnar synostosis, nonsyndromic}, OMIM:179300
    Green SMAD6 in Rare syndromic craniosynostosis or isolated multisuture synostosis


    Level 2: Musculoskeletal
    Version 6.3
    Latest signed off version: v6.0 (30 Apr 2025)

    review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • NHS GMS
    • Expert Review Green
    • Literature
    Phenotypes
    • metopic synostosis
    • sagittal synostosis
    • {Craniosynostosis 7, susceptibility to} 617439
    Tags
    • polygenic
    • curated-variant-list
    Red SMAD6 in DDG2P


    Version 6.424
    Latest signed off version: v6.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Paediatric disorders
  • review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Red
    • DD-Gene2Phenotype
    Phenotypes
    • Non-syndromic craniosynostosis
    Green SMAD6 in Syndromic and non syndromic craniosynostosis involving midline sutures


    Level 2: Musculoskeletal
    Version 1.3
    Latest signed off version: v1.0 (14 Sep 2023)

    review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • NHS GMS
    • Expert Review Green
    Phenotypes
    • {Craniosynostosis 7, susceptibility to}, OMIM:617439
    • craniosynostosis 7, MONDO:0044315