TMC8

transmembrane channel like 8
OMIM: 605829, Gene2Phenotype

6 panels

Panel Reviews Mode of inheritance Details
6 panels
Green TMC8 in COVID-19 research


Level 2: Viral research
Version 1.141

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
  • Melbourne Genomics Health Alliance Immunology Flagship
  • NHS GMS
  • North West GLH
  • London North GLH
  • Expert Review Green
  • IUIS Classification February 2018
  • Victorian Clinical Genetics Services
  • ESID Registry 20171117
  • GRID V2.0
  • Literature
Phenotypes
  • HPV (group B1) infections and cancer of the skin (typical EV)
  • Epidermodysplasia verruciformis, 226400
  • Defects in Intrinsic and Innate Immunity
  • Epidermodysplasia Verruciformis
Green TMC8 in Pigmentary skin disorders


Version 3.10
Latest signed off version: v3.0 (22 Mar 2023)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • London North GLH
  • NHS GMS
  • Expert Review Green
Phenotypes
  • EPIDERMODYSPLASIA VERRUCIFORMIS, SUSCEPTIBILITY TO, 2
  • Epidermodysplasia verruciformis 2, 618231
  • EV2
Green TMC8 in Epidermodysplasia verruciformis


Version 1.6
Latest signed off version: v1.3 (15 Oct 2020)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • London North GLH
  • NHS GMS
  • Expert Review Green
Phenotypes
  • Epidermodysplasia verruciformis 2, 618231
Green TMC8 in Primary immunodeficiency or monogenic inflammatory bowel disease


Version 4.191
Latest signed off version: v4.0 (22 Mar 2023)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • NHS GMS
  • North West GLH
  • London North GLH
  • Expert Review Green
  • IUIS Classification February 2018
  • Victorian Clinical Genetics Services
  • ESID Registry 20171117
  • GRID V2.0
Phenotypes
  • Epidermodysplasia verruciformis, 226400
  • HPV (group B1) infections and cancer of the skin (typical EV)
  • Defects in Intrinsic and Innate Immunity
No list TMC8 in Multiple monogenic benign skin tumours


Version 2.4
Latest signed off version: v2.0 (30 Nov 2022)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Removed
  • London North GLH
  • NHS GMS
Phenotypes
  • Epidermodysplasia verruciformis 2, 618231
  • Epidermodysplasia verruciformis
Tags
  • curated_removed
Green TMC8 in Severe Paediatric Disorders


Version 1.182

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Next Generation Children Project
  • Expert Review Green
  • Expert list
Phenotypes
  • Epidermodysplasia verruciformis 2, 618231