TNNI3

troponin I3, cardiac type
OMIM: 191044, Gene2Phenotype

7 panels

Panel Reviews Mode of inheritance Details
7 panels
Red TNNI3 in Left Ventricular Noncompaction Cardiomyopathy

Level 3: Cardiomyopathy
Level 2: Cardiovascular disorders
Version 1.4

review Not set
Sources
  • Expert Review Red
  • Eligibility statement prior genetic testing
Phenotypes
  • Hypertrophic cardiomyopathy
Green TNNI3 in Hypertrophic cardiomyopathy

Level 3: Cardiomyopathy
Level 2: Cardiovascular disorders
Version 4.13
Latest signed off version: v4.8 (1 May 2024)

Component of the following Super Panels:

  • Sudden unexplained death or survivors of a cardiac event
  • Unexplained death in infancy and sudden unexplained death in childhood
  • review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • South West GLH
    • London South GLH
    • North West GLH
    • Expert Review Green
    • Eligibility statement prior genetic testing
    • Expert list
    • Illumina TruGenome Clinical Sequencing Services
    • Radboud University Medical Center, Nijmegen
    • Emory Genetics Laboratory
    • UKGTN
    Phenotypes
    • Cardiomyopathy, familial hypertrophic, 7
    • ?Cardiomyopathy, dilated, 2A (611880)
    • Cardiomyopathy, dilated, 1FF (613286)
    • Cardiomyopathy, familial restrictive, 1 (115210)
    • Cardiomyopathy, hypertrophic, 7 (613690)
    Green TNNI3 in Dilated Cardiomyopathy and conduction defects

    Level 3: Cardiomyopathy
    Level 2: Cardiovascular disorders
    Version 1.94

    review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • South West GLH
    • London South GLH
    • North West GLH
    • Expert Review Green
    • UKGTN
    • Expert list
    • Emory Genetics Laboratory
    • Illumina TruGenome Clinical Sequencing Services
    • Radboud University Medical Center, Nijmegen
    Phenotypes
    • Cardiomyopathy, dilated, 1FF (613286)
    • Cardiomyopathy, dilated, 1FF
    • Cardiomyopathy, dilated, 2A,
    • Cardiomyopathy, familial restrictive, 1 (115210)
    • Cardiomyopathy, hypertrophic, 7 (613690)
    • ?Cardiomyopathy, dilated, 2A (611880)
    Green TNNI3 in Dilated and arrhythmogenic cardiomyopathy

    Level 3: Cardiomyopathy
    Level 2: Cardiovascular disorders
    Version 2.31
    Latest signed off version: v2.23 (1 May 2024)

    Component of the following Super Panels:

  • Sudden unexplained death or survivors of a cardiac event
  • Unexplained death in infancy and sudden unexplained death in childhood
  • review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • UKGTN
    • South West GLH
    • Radboud University Medical Center, Nijmegen
    • Illumina TruGenome Clinical Sequencing Services
    • London South GLH
    • North West GLH
    • Expert list
    • Emory Genetics Laboratory
    • South West GLH
    • London South GLH
    • North West GLH
    Phenotypes
    • Cardiomyopathy, dilated, 1FF (613286)
    • Cardiomyopathy, dilated, 2A,
    • ?Cardiomyopathy, dilated, 2A (611880)
    • Cardiomyopathy, familial restrictive, 1 (115210)
    • Cardiomyopathy, dilated, 1FF
    • Cardiomyopathy, hypertrophic, 7 (613690)
    Red TNNI3 in Hereditary neuropathy

    Level 3: Motor and Sensory Disorders of the PNS
    Level 2: Neurology and neurodevelopmental disorders
    Version 1.478

    review Not set
    Sources
    • NHS GMS
    • South West GLH
    • Emory Genetics Laboratory
    Phenotypes
    • Cardiomyopathy
    Green TNNI3 in Paediatric or syndromic cardiomyopathy


    Version 4.7
    Latest signed off version: v4.0 (1 May 2024)

    Component of the following Super Panels:

  • Unexplained death in infancy and sudden unexplained death in childhood
  • review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • NHS GMS
    • South West GLH
    • London South GLH
    • Expert Review Green
    Phenotypes
    • Hypertrophic cardiomyopathy
    • Cardiomyopathy, familial hypertrophic, 7
    • Cardiomyopathy, dilated, 1FF
    • Cardiomyopathy, dilated, 2A,
    Red TNNI3 in Hereditary neuropathy or pain disorder


    Version 4.11
    Latest signed off version: v4.0 (1 May 2024)

    review Not set
    Sources
    • NHS GMS
    • South West GLH
    • Emory Genetics Laboratory
    • NHS GMS
    • South West GLH
    Phenotypes
    • Cardiomyopathy