TREM2

triggering receptor expressed on myeloid cells 2
OMIM: 605086, Gene2Phenotype

12 panels

Panel Reviews Mode of inheritance Details
12 panels

Red TREM2 in Early onset dementia (encompassing fronto-temporal dementia and prion disease)

Level 3: Neurodegenerative disorders
Level 2: Neurology and neurodevelopmental disorders
Version 1.76

review Not set
Sources
  • UKGTN
Phenotypes
  • Dementia

Red TREM2 in Early onset dystonia

Level 3: Motor Disorders of the CNS
Level 2: Neurology and neurodevelopmental disorders
Version 1.117

review Not set
Sources
  • Emory Genetics Laboratory
Phenotypes
  • Dystonia

Green TREM2 in White matter disorders and cerebral calcification - narrow panel


Version 1.240
Latest signed off version: v1.12 (2 Mar 2020)

Component of the following Super Panels:

  • White matter disorders - childhood onset
  • review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    Phenotypes
    • POLYCYSTIC LIPOMEMBRANOUS OSTEODYSPLASIA WITH SCLEROSING LEUKOENCEPHALOPATHY
    • Calcifications in basal ganglia
    • Nasu-Hakola disease
    • Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL)

    Green TREM2 in White matter disorders - adult onset


    Version 1.43
    Latest signed off version: v1.25 (5 Aug 2021)

    review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • NHS GMS
    • Yorkshire and North East GLH
    Phenotypes
    • Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2, 618193

    Green TREM2 in Intracerebral calcification disorders

    Level 3: Parenchymal brain disorders
    Level 2: Neurology and neurodevelopmental disorders
    Version 1.34

    review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Emory Genetics Laboratory
    Phenotypes
    • Calcifications in basal ganglia
    • Nasu-Hakola disease
    • Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL)

    Red TREM2 in Inherited white matter disorders

    Level 3: White matter disorders
    Level 2: Neurology and neurodevelopmental disorders
    Version 1.159

    review Not set
    Sources
    • UKGTN
    Phenotypes
    • POLYCYSTIC LIPOMEMBRANOUS OSTEODYSPLASIA WITH SCLEROSING LEUKOENCEPHALOPATHY

    Green TREM2 in Skeletal dysplasia

    Level 3: Skeletal dysplasias
    Level 2: Skeletal disorders
    Version 2.208
    Latest signed off version: v2.2 (13 Feb 2020)

    Component of the following Super Panels:

  • Paediatric disorders
  • review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • NHS GMS
    • Expert Review Green
    • Illumina TruGenome Clinical Sequencing Services
    • UKGTN
    • Expert list
    • Radboud University Medical Center, Nijmegen
    • Emory Genetics Laboratory
    Phenotypes
    • Nasu-Hakola disease 221770

    Green TREM2 in Neurodegenerative disorders - adult onset


    Version 2.275
    Latest signed off version: v2.178 (5 Aug 2021)

    review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Yorkshire and North East GLH
    • Expert Review Green
    • NHS GMS
    • London North GLH
    Phenotypes
    • Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2, OMIM:618193
    • Dystonia

    Red TREM2 in Osteogenesis imperfecta

    Level 3: Skeletal dysplasias
    Level 2: Skeletal disorders
    Version 2.48
    Latest signed off version: v2.2 (13 Feb 2020)

    review Not set
    Sources
    • Emory Genetics Laboratory
    Phenotypes
    • Osteogenesis Imperfecta and Decreased Bone Density
    • skeletal dysplasias

    Red TREM2 in Adult onset movement disorder


    Version 1.170
    Latest signed off version: v1.121 (5 Aug 2021)

    review Not set
    Sources
    • NHS GMS
    • South West GLH
    • Expert Review Red
    Phenotypes
    • Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2, 618193
    • Frontotemporal dementia
    • Alzheimers disease
    • Dystonia

    Red TREM2 in Childhood onset dystonia or chorea or related movement disorder


    Version 1.240
    Latest signed off version: v1.137 (5 Aug 2021)

    review Not set
    Sources
    • South West GLH
    Phenotypes
    • Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2, 618193
    • Alzheimers disease
    • Frontotemporal dementia

    Green TREM2 in Severe Paediatric Disorders


    Version 1.127

    review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Next Generation Children Project
    • Expert Review Green
    • Expert list
    Phenotypes
    • Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2, 618193