1. Genes and Genomic Entities
  2. TRPM7

TRPM7

transient receptor potential cation channel subfamily M member 7
OMIM: 605692, Gene2Phenotype

4 panels

Panel Reviews Mode of inheritance Details
4 panels
Amber TRPM7 in Bleeding and platelet disorders


Level 2: Haematology
Version 4.17
Latest signed off version: v4.16 (12 Aug 2026)

review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Amber
  • NHS GMS
  • Wessex and West Midlands GLH
Phenotypes
  • macrothrombocytopenia
Green TRPM7 in Likely inborn error of metabolism


Level 2: Metabolic
Version 9.30
Latest signed off version: v9.29 (12 Aug 2026)

Component of the following Super Panels:

  • Hypotonic infant
  • Leukodystrophy, childhood onset
  • Paediatric disorders
  • Unexplained death in infancy and sudden unexplained death in childhood

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • NHS GMS
    • Literature
    Phenotypes
    • hypomagnesaemia with secondary hypocalcaemia
    Red TRPM7 in Fetal anomalies


    Level 2: Fetal (including NIPD)
    Version 8.5
    Latest signed off version: v8.0 (12 Aug 2026)

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • NHS GMS
    • Literature
    Phenotypes
    • Amyotrophic lateral sclerosis-parkinsonism/dementia complex, susceptibility to, OMIM:105500
    • Cardiac arrhythmia, stillbirth
    Green TRPM7 in Early onset or syndromic epilepsy


    Level 2: Neurology
    Version 9.73
    Latest signed off version: v9.56 (12 Aug 2026)

    Component of the following Super Panels:

  • Paediatric disorders
  • Unexplained death in infancy and sudden unexplained death in childhood

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • NHS GMS
    • Literature
    Phenotypes
    • hypomagnesaemia with secondary hypocalcaemia