1. Genes and Genomic Entities
  2. WARS

WARS

tryptophanyl-tRNA synthetase
OMIM: 191050, Gene2Phenotype

5 panels

Panel Reviews Mode of inheritance Details
5 panels
Amber WARS in Severe microcephaly


Level 2: Neurology
Version 8.31
Latest signed off version: v8.0 (30 Apr 2025)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Literature
  • Expert Review Amber
Phenotypes
  • Neurodevelopmental disorder with microcephaly and speech delay, with or without brain abnormalities, OMIM:620317
  • neurodevelopmental disorder with microcephaly and speech delay, with or without brain abnormalities, MONDO:0957218
Tags
  • Q3_25_promote_green
Green WARS in DDG2P


Version 6.424
Latest signed off version: v6.0 (30 Apr 2025)

Component of the following Super Panels:

  • Paediatric disorders

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • DD-Gene2Phenotype
    • Expert Review Green
    Phenotypes
    • WARS1-associated neurodevelopmental syndrome
    • Distal hereditary motor neuropathy
    Tags
    • new-gene-name
    Green WARS in Hereditary neuropathy

    Level 3: Motor and Sensory Disorders of the PNS
    Level 2: Neurology and neurodevelopmental disorders
    Version 1.506

    		review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • NHS GMS
    • London North GLH
    Phenotypes
    • Neuronopathy, distal hereditary motor, type IX, 617721
    Tags
    • new-gene-name
    Amber WARS in Intellectual disability


    Level 2: Developmental disorders
    Version 9.279
    Latest signed off version: v9.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Childhood onset leukodystrophy
  • Hypotonic infant
  • Paediatric disorders

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Amber
    • Literature
    Phenotypes
    • Neurodevelopmental disorder with microcephaly and speech delay, with or without brain abnormalities, OMIM:620317
    • neurodevelopmental disorder with microcephaly and speech delay, with or without brain abnormalities, MONDO:0957218
    Tags
    • Q3_25_promote_green
    Green WARS in Hereditary neuropathy or pain disorder


    Level 2: Neurology
    Version 7.36
    Latest signed off version: v7.0 (30 Apr 2025)

    		review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • London North GLH
    • NHS GMS
    • Expert Review Green
    • NHS GMS
    • London North GLH
    Phenotypes
    • Neuronopathy, distal hereditary motor, type IX, 617721
    Tags
    • new-gene-name