Hereditary neuropathyGene: WARS
Mutations present in several unrelated families. Additional cases on GEL
Created: 9 May 2019, 12:24 p.m.
The Neurology Specialist Test Group agreed that this gene was recommended for the WGS panel based on a broader phenotype view to include conditions where neuropathy is part of a more complex phenotype or where there is overlap with another neurological presentation eg. HSP. This panel includes conditions where neuropathy is part of a more complex phenotype or where there is overlap with another neurological presentation. This panel as going to be used for R78, but subsequently during the follow up call on 21st June with the Test Group it was agreed that it was more clinically relevant for R78 to be restricted to genes that are associated with isolated neuropathy and as a result a new panel was created https://panelapp.genomicsengland.co.uk/panels/846/ for this purpose.
Created: 7 Dec 2019, 6:08 p.m. | Last Modified: 7 Dec 2019, 6:08 p.m.
Panel Version: 1.352
Comment on list classification: new gene added from the GLH, this gene was rated as Green due to cases in the 100,000 Genomes Project in addition to the published cases
Created: 12 Nov 2019, 11:09 a.m. | Last Modified: 12 Nov 2019, 11:09 a.m.
Panel Version: 1.337
Added new-gene-name tag, new approved HGNC gene symbol for WARS is WARS1
Created: 6 Sep 2019, 2:49 p.m. | Last Modified: 6 Sep 2019, 2:49 p.m.
Panel Version: 1.333
Review and rating uploaded from file (Curation_Template_GMS_Neuro_AR_20190521.xlsx) submitted by Alex Rossor (UCL Institute of Neurology) on behalf of London North GLH for GMS Neurology specialist test group.
Created: 11 Jun 2019, 1:40 p.m.
Rating and review submitted on behalf of James Polke (Neurogenetics Laboratory,Institute of Neurology, London), on behalf of London North GLH for GMS Neurology specialist test group.
Created: 9 May 2019, 5 p.m.
Gene: wars has been classified as Green List (High Evidence).
Publications for gene: WARS were set to
Tag new-gene-name tag was added to gene: WARS.
Mode of inheritance for gene: WARS was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes for gene: WARS were changed from to Neuronopathy, distal hereditary motor, type IX, 617721
Source NHS GMS was added to WARS.
gene: WARS was added gene: WARS was added to Hereditary neuropathy. Sources: London North GLH Mode of inheritance for gene: WARS was set to