Genes in panel

Hereditary neuropathy

Gene: WARS

Green List (high evidence)

WARS (tryptophanyl-tRNA synthetase)
EnsemblGeneIds (GRCh38): ENSG00000140105
EnsemblGeneIds (GRCh37): ENSG00000140105
OMIM: 191050, Gene2Phenotype
WARS is in 2 panels

3 reviews

Alexander Rossor (UCL Institute of Neurology)

Green List (high evidence)

Mutations present in several unrelated families. Additional cases on GEL
Created: 9 May 2019, 12:24 p.m.

Louise Daugherty (Genomics England Curator)

Green List (high evidence)

The Neurology Specialist Test Group agreed that this gene was recommended for the WGS panel based on a broader phenotype view to include conditions where neuropathy is part of a more complex phenotype or where there is overlap with another neurological presentation eg. HSP. This panel includes conditions where neuropathy is part of a more complex phenotype or where there is overlap with another neurological presentation. This panel as going to be used for R78, but subsequently during the follow up call on 21st June with the Test Group it was agreed that it was more clinically relevant for R78 to be restricted to genes that are associated with isolated neuropathy and as a result a new panel was created https://panelapp.genomicsengland.co.uk/panels/846/ for this purpose.
Created: 7 Dec 2019, 6:08 p.m. | Last Modified: 7 Dec 2019, 6:08 p.m.
Panel Version: 1.352
Comment on list classification: new gene added from the GLH, this gene was rated as Green due to cases in the 100,000 Genomes Project in addition to the published cases
Created: 12 Nov 2019, 11:09 a.m. | Last Modified: 12 Nov 2019, 11:09 a.m.
Panel Version: 1.337
Added new-gene-name tag, new approved HGNC gene symbol for WARS is WARS1
Created: 6 Sep 2019, 2:49 p.m. | Last Modified: 6 Sep 2019, 2:49 p.m.
Panel Version: 1.333
Review and rating uploaded from file (Curation_Template_GMS_Neuro_AR_20190521.xlsx) submitted by Alex Rossor (UCL Institute of Neurology) on behalf of London North GLH for GMS Neurology specialist test group.
Created: 11 Jun 2019, 1:40 p.m.
Rating and review submitted on behalf of James Polke (Neurogenetics Laboratory,Institute of Neurology, London), on behalf of London North GLH for GMS Neurology specialist test group.
Created: 9 May 2019, 5 p.m.

James Polke (Neurogenetics Laboratory, Institute of Neurology, London)

Green List (high evidence)

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Green
  • NHS GMS
  • London North GLH
Phenotypes
  • Neuronopathy, distal hereditary motor, type IX, 617721
Tags
new-gene-name
OMIM
191050
Clinvar variants
Variants in WARS
Penetrance
None
Publications
Panels with this gene

History Filter Activity

12 Nov 2019, Gel status: 3

Entity classified by Genomics England curator

Louise Daugherty (Genomics England Curator)

Gene: wars has been classified as Green List (High Evidence).

12 Nov 2019, Gel status: 1

Set publications

Louise Daugherty (Genomics England Curator)

Publications for gene: WARS were set to

6 Sep 2019, Gel status: 1

Added Tag

Louise Daugherty (Genomics England Curator)

Tag new-gene-name tag was added to gene: WARS.

5 Jun 2019, Gel status: 1

Set mode of inheritance

Louise Daugherty (Genomics England Curator)

Mode of inheritance for gene: WARS was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

5 Jun 2019, Gel status: 1

Set Phenotypes

Louise Daugherty (Genomics England Curator)

Phenotypes for gene: WARS were changed from to Neuronopathy, distal hereditary motor, type IX, 617721

29 Apr 2019, Gel status: 1

Added New Source

Louise Daugherty (Genomics England Curator)

Source NHS GMS was added to WARS.

29 Apr 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance

Louise Daugherty (Genomics England Curator)

gene: WARS was added gene: WARS was added to Hereditary neuropathy. Sources: London North GLH Mode of inheritance for gene: WARS was set to