Hereditary neuropathy
Gene: MRE11
Unable to find any evidence of clear neuropathy association. Caution needed due to cancer associationsCreated: 29 Apr 2019, 12:30 p.m.
Phenotypes
Hereditary Neuropathies
Review and rating submitted by Natalie Forrester (SWGLH - Bristol Genetics) on behalf of South West GLH for GMS Neurology specialist test group.Created: 29 Apr 2019, 12:53 p.m.
added new-gene-name tag - approved gene symbol MRE11.
Nomenclature history profile of this gene (from correspondence with HGNC) : a change was made in the 1990s of the gene symbol MRE11 to MRE11A which left a withdrawn MRE11 gene symbol even though this was really just a rename. Then, recently, MRE11A was named back to MRE11after MRE11B turned out to be a pseudogene and was renamed to MRE11P1. HGNC will now delete the MRE11~withdrawn symbol so that this confusion will not occur again. There is now only one MRE11 record, with HGNC:7230.Created: 4 Aug 2017, 8:05 a.m.
Not a CMT geneCreated: 9 Dec 2015, 8:49 a.m.
Not a CMT geneCreated: 8 Dec 2015, 3:06 p.m.
Added phenotypes Hereditary Neuropathies for gene: MRE11
Source NHS GMS was added to MRE11.
Source South West GLH was added to MRE11.
MRE11A was changed to MRE11
new-gene-name was removed from MRE11A. Panel: Charcot-Marie-Tooth disease
MRE11A was added to Charcot-Marie-Tooth diseasepanel. Sources: Emory Genetics Laboratory