YARS

tyrosyl-tRNA synthetase
OMIM: 603623, Gene2Phenotype

5 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 5 panels
Green YARS in Cholestasis Level 2: Gastrohepatology Version 4.19 Latest signed off version: v4.17 (12 Aug 2026)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Literature Phenotypes Infantile-onset multisystem neurologic, endocrine, and pancreatic disease 2, OMIM:619418 neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 2, MONDO:0030375 Tags new-gene-name
Green YARS in Hereditary neuropathy Level 3: Motor and Sensory Disorders of the PNS Level 2: Neurology and neurodevelopmental disorders Version 1.513	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources South West GLH NHS GMS London North GLH Expert Review Green Emory Genetics Laboratory UKGTN Expert list Radboud University Medical Center, Nijmegen Illumina TruGenome Clinical Sequencing Services Phenotypes Charcot Marie Tooth disease, dominant intermediate C, 608323 Charcot Marie Tooth disease, dominant intermediate C, 608323 Tags new-gene-name
Amber YARS in Monogenic hearing loss Level 2: Audiology Version 6.46 Latest signed off version: v6.34 (12 Aug 2026) Component of the following Super Panels: Paediatric disorders	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Amber Literature Phenotypes Infantile-onset multisystem neurologic, endocrine, and pancreatic disease 2, OMIM:619418 neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 2, MONDO:0030375 hearing loss disorder, MONDO:0005365 Tags new-gene-name Q4_26_promote_green
Amber YARS in Intellectual disability Level 2: Developmental disorders Version 11.44 Latest signed off version: v11.0 (12 Aug 2026) Component of the following Super Panels: Hypotonic infant Leukodystrophy, childhood onset Paediatric disorders	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Amber Literature Phenotypes Infantile-onset multisystem neurologic, endocrine, and pancreatic disease 2, OMIM:619418 neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 2, MONDO:0030375 Tags new-gene-name Q4_26_promote_green
Green YARS in Hereditary neuropathy or pain disorder Level 2: Neurology Version 8.38 Latest signed off version: v8.30 (12 Aug 2026)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Radboud University Medical Center, Nijmegen South West GLH Expert Review Green UKGTN Emory Genetics Laboratory Expert list London North GLH Illumina TruGenome Clinical Sequencing Services NHS GMS South West GLH NHS GMS London North GLH Phenotypes Charcot Marie Tooth disease, dominant intermediate C, 608323 Tags new-gene-name