1. Genes and Genomic Entities
  2. ZFHX3

ZFHX3

zinc finger homeobox 3
OMIM: 104155, Gene2Phenotype

6 panels

Panel Reviews Mode of inheritance Details
6 panels
Red ZFHX3 in COVID-19 research


Level 2: Viral research
Version 1.147

review Not set
Sources
  • Literature
Red ZFHX3 in Ataxia and cerebellar anomalies - childhood onset


Level 2: Neurology
Version 9.41
Latest signed off version: v9.22 (12 Aug 2026)

Component of the following Super Panels:

  • Hereditary ataxia and cerebellar anomalies, childhood onset

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Red
    • Literature
    Phenotypes
    • Spinocerebellar ataxia 4, OMIM:600223
    • spinocerebellar ataxia type 4, MONDO:0010847
    Tags
    • STR
    Amber ZFHX3 in Fetal anomalies


    Level 2: Fetal (including NIPD)
    Version 8.31
    Latest signed off version: v8.0 (12 Aug 2026)

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • NHS GMS
    • Expert Review Amber
    Phenotypes
    • neural tube defect, MONDO:0018075
    Green ZFHX3 in DDG2P


    Version 8.2
    Latest signed off version: v8.0 (12 Aug 2026)

    Component of the following Super Panels:

  • Paediatric disorders

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • DD-Gene2Phenotype
    Phenotypes
    • ZFHX3-related developmental disorder (monoallelic)
    Tags
    • de novo
    Green ZFHX3 in Intellectual disability


    Level 2: Developmental disorders
    Version 11.72
    Latest signed off version: v11.0 (12 Aug 2026)

    Component of the following Super Panels:

  • Hypotonic infant
  • Leukodystrophy, childhood onset
  • Paediatric disorders

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • NHS GMS
    • Literature
    Phenotypes
    • syndromic intellectual disability
    Red ZFHX3_GGC STR in Ataxia and cerebellar anomalies - childhood onset


    Level 2: Neurology
    Version 9.41
    Latest signed off version: v9.22 (12 Aug 2026)

    Component of the following Super Panels:

  • Hereditary ataxia and cerebellar anomalies, childhood onset

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Literature
    Phenotypes
    • Spinocerebellar ataxia 4, OMIM:600223
    Tags
    • STR
    • NGS Not Validated