Early onset and familial Parkinson's Disease

Gene: MAPT

PMID: 28334843 - new publication providing further evidence. Autophagy-upregulating therapies may be a strategy for the treatment for tauopathies.

Created: 14 Aug 2017, 3:26 p.m.

Comment on list classification: Is on the Dementia NGS Panel in the UCLH National Hospital for Neurology and Neurosurgery & Institute of Neurology (NHNN) Neurogenetics genetic testing manual, and consideration of testing for this gene is suggested in the case of familial or unusual syndromes, which may include earlier age of onset: "Complicated parkinsonism such as MSA and PSP generally do not appear to have a high recurrence risk. However, in the case of familial or unusual syndromes, which may include earlier age of onset, consideration to sequence the MAPT gene is suggested. In MSA approximately 10% of patients have a spinocerebellar ataxia (SCA) expansion."

Created: 10 Jun 2016, 10:45 a.m.

Publications

• 28334843