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  3. SNCA
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Early onset and familial Parkinson's Disease

Gene: SNCA

Green List (high evidence)
SNCA (synuclein alpha)
EnsemblGeneIds (GRCh38): ENSG00000145335
EnsemblGeneIds (GRCh37): ENSG00000145335
OMIM: 163890, Gene2Phenotype
SNCA is in 5 panels

1 review

Ellen McDonagh (Genomics England Curator)

Comment on list classification: Is on the Parkinson's Disease NGS Panel in the UCLH National Hospital for Neurology and Neurosurgery & Institute of Neurology (NHNN) Neurogenetics genetic testing manual.
Created: 10 Jun 2016, 10:29 a.m.
Created: 10 Jun 2016, 10:29 a.m.

Panel version: 0.12

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Green
  • UKGTN
  • Illumina TruGenome Clinical Sequencing Services
  • Expert
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • Parkinson disease 4, 605543
  • Dementia, Lewy body, 127750
  • Parkinson disease 1, 168601
  • Parkinson Disease, Dominant
  • PARKINSON DISEASE 1, AUTOSOMAL DOMINANT
  • PARKINSON DISEASE 4, AUTOSOMAL DOMINANT
  • DEMENTIA, LEWY BODY
  • Autosomal dominant Parkinson's disease with alpha-synuclein rearrangements (PARK1/4)
OMIM
163890
Clinvar variants
Variants in SNCA
Penetrance
Complete
Panels with this gene

History Filter Activity

10 Jun 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

10 Jun 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

10 Jun 2016, Gel status: 3

Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Phenotypes for SNCA were set to Parkinson disease 4, 605543; Dementia, Lewy body, 127750; Parkinson disease 1, 168601; Parkinson Disease, Dominant; PARKINSON DISEASE 1, AUTOSOMAL DOMINANT; PARKINSON DISEASE 4, AUTOSOMAL DOMINANT; DEMENTIA, LEWY BODY; Autosomal dominant Parkinson's disease with alpha-synuclein rearrangements (PARK1/4)

24 Jul 2015, Gel status: 3

Added New Source

Ellen McDonagh (Genomics England Curator)

SNCA was added to Early onset and familial Parkinson's Diseasepanel. Sources: UKGTN

24 Jul 2015, Gel status: 2

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene SNCA was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

24 Jul 2015, Gel status: 2

Added New Source

Ellen McDonagh (Genomics England Curator)

SNCA was added to Early onset and familial Parkinson's Diseasepanel. Sources: Illumina TruGenome Clinical Sequencing Services

24 Jul 2015, Gel status: 1

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene SNCA was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

24 Jul 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

SNCA was added to Early onset and familial Parkinson's Diseasepanel. Sources: Radboud University Medical Center, Nijmegen,Expert

24 Jul 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

SNCA was added to Early onset and familial Parkinson's Diseasepanel. Sources: Radboud University Medical Center, Nijmegen,Expert