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  2. Familial Neural Tube Defects
  3. DLL3
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Familial Neural Tube Defects

Gene: DLL3

Red List (low evidence)
DLL3 (delta like canonical Notch ligand 3)
EnsemblGeneIds (GRCh38): ENSG00000090932
EnsemblGeneIds (GRCh37): ENSG00000090932
OMIM: 602768, Gene2Phenotype
DLL3 is in 6 panels

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Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Red
  • UKGTN
  • Illumina TruGenome Clinical Sequencing Services
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • Spondylocostal dysostosis 1
  • Spondylocostal Dysostosis
OMIM
602768
Clinvar variants
Variants in DLL3
Penetrance
Complete
Panels with this gene

History Filter Activity

25 Oct 2016, Gel status: 1

panel promoted to version 1

Ellen McDonagh (Genomics England Curator)

25th Oct 2016: This panel was discussed internally, and as Neural tube defects (NTDs) are common multifactorial disorders caused by multiple genes and environmental factors, all genes on this panel should be considered red at this stage. Ready to promote to Version 1.

25 Oct 2016, Gel status: 1

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

22 Sep 2016, Gel status: 3

Added New Source

Olivia Niblock (Genomics England Curator)

DLL3 was added to Familial Neural Tube Defectspanel. Source: UKGTN

22 Sep 2016, Gel status: 2

Added New Source

Olivia Niblock (Genomics England Curator)

DLL3 was added to Familial Neural Tube Defectspanel. Source: Illumina TruGenome Clinical Sequencing Services

22 Sep 2016, Gel status: 0

Created

Olivia Niblock (Genomics England Curator)

DLL3 was created by oniblock

22 Sep 2016, Gel status: 1

Added New Source

Olivia Niblock (Genomics England Curator)

DLL3 was added to Familial Neural Tube Defectspanel. Sources: Radboud University Medical Center, Nijmegen