Multi locus imprinting disorders
Gene: GRB10
Comment on list classification: This gene has been demoted to Amber as it is not appropriate for the NHS clinical indication R417 Multi locus imprinting disorders (https://www.england.nhs.uk/publication/national-genomic-test-directories).Created: 17 Feb 2022, 1:57 p.m. | Last Modified: 17 Feb 2022, 1:57 p.m.
Panel Version: 0.11
Not associated with a phenotype in OMIM, Gen2Phen or MONDO. The imprinted gene, GRB10, has been associated with Silver-Russell syndrome 2, OMIM:618905 in cases with duplication of 7p including GRB10 (PMID: 10631135;12384779;10987657;33187293).Created: 21 Jan 2022, 8:01 a.m. | Last Modified: 21 Jan 2022, 8:01 a.m.
Panel Version: 0.3
Imprinted, isoform-specific expression.Created: 22 Dec 2020, 6:10 p.m. | Last Modified: 22 Dec 2020, 6:10 p.m.
Panel Version: 0.26
Publications
Gene: grb10 has been classified as Amber List (Moderate Evidence).
Gene: grb10 has been classified as Green List (High Evidence).
Phenotypes for gene: GRB10 were changed from Silver-Russell syndrome to Silver-Russell syndrome 2, OMIM:618905
gene: GRB10 was added gene: GRB10 was added to Multi locus imprinting disorders. Sources: Literature,Expert Review Amber Mode of inheritance for gene: GRB10 was set to MONOALLELIC, autosomal or pseudoautosomal, paternally imprinted (maternal allele expressed) Publications for gene: GRB10 were set to 10861285; 10856193; 27370225; 10856193; 11112662; 30794780; http://igc.otago.ac.nz/home.html Phenotypes for gene: GRB10 were set to Silver-Russell syndrome