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Acute rhabdomyolysis

Gene: CYP2C8

Red List (low evidence)
CYP2C8 (cytochrome P450 family 2 subfamily C member 8)
EnsemblGeneIds (GRCh38): ENSG00000138115
EnsemblGeneIds (GRCh37): ENSG00000138115
OMIM: 601129, Gene2Phenotype
CYP2C8 is in 2 panels

2 reviews

Achchuthan Shanmugasundram (Genomics England Curator)

Red List (low evidence)

The rating of this gene remains red as the MOI is unknown and rhabdomyolysis is drug-induced rather than inherited.
Created: 6 Jul 2024, 10:43 a.m. | Last Modified: 6 Jul 2024, 10:43 a.m.
Panel Version: 1.18
Created: 6 Jul 2024, 10:43 a.m.
Last Modified: 6 Jul 2024, 10:43 a.m.
Panel version: 1.18

Arina Puzriakova (Genomics England Curator)

Red List (low evidence)

Added 'to_be_confirmed_NHSE' tag - testing criteria to be discussed as CYP2C8-related rhabdomyolysis is drug-induced
Created: 16 Feb 2022, 2:19 p.m. | Last Modified: 16 Feb 2022, 2:19 p.m.
Panel Version: 0.5
CYP2C8 is rated Red on the GMS 'Rhabdomyolysis and metabolic muscle disorders panel' (version 1.75) panel. Variants in CYP2C8 can alter drug metabolism and in turn lead to statin-related (specifically cerivastatin) rhabdomyolysis rather than inherited rhabdomyolysis. Some susceptibility alleles can be found at low frequencies in population databases.
Created: 19 Jan 2022, 5:51 p.m. | Last Modified: 19 Jan 2022, 5:51 p.m.
Panel Version: 0.3

Mode of inheritance
Unknown

Phenotypes
{Drug metabolism, altered, CYP2C8-related}, OMIM:618018; Rhabdomyolysis, cerivastatin-induced

Publications

Created: 19 Jan 2022, 5:51 p.m.
Last Modified: 19 Jan 2022, 5:51 p.m.
Panel version: 0.5

Details

Mode of Inheritance
Unknown
Sources
  • NHS GMS
  • Expert Review Red
Phenotypes
  • Rhabdomyolysis, cerivastatin-induced
  • {Drug metabolism, altered, CYP2C8-related}, OMIM:618018
OMIM
601129
Clinvar variants
Variants in CYP2C8
Penetrance
None
Publications
Panels with this gene

History Filter Activity

5 Jul 2024, Gel status: 1

Removed Tag

Achchuthan Shanmugasundram (Genomics England Curator)

Tag to_be_confirmed_NHSE was removed from gene: CYP2C8.

16 Feb 2022, Gel status: 1

Added Tag

Arina Puzriakova (Genomics England Curator)

Tag to_be_confirmed_NHSE tag was added to gene: CYP2C8.

19 Jan 2022, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Arina Puzriakova (Genomics England Curator)

gene: CYP2C8 was added gene: CYP2C8 was added to Acute rhabdomyolysis. Sources: Expert Review Red,NHS GMS Mode of inheritance for gene: CYP2C8 was set to Unknown Publications for gene: CYP2C8 were set to 20739906; 15365880 Phenotypes for gene: CYP2C8 were set to Rhabdomyolysis, cerivastatin-induced; {Drug metabolism, altered, CYP2C8-related}, OMIM:618018