Acute rhabdomyolysis
Gene: CYP2C8
Added 'to_be_confirmed_NHSE' tag - testing criteria to be discussed as CYP2C8-related rhabdomyolysis is drug-inducedCreated: 16 Feb 2022, 2:19 p.m. | Last Modified: 16 Feb 2022, 2:19 p.m.
Panel Version: 0.5
CYP2C8 is rated Red on the GMS 'Rhabdomyolysis and metabolic muscle disorders panel' (version 1.75) panel. Variants in CYP2C8 can alter drug metabolism and in turn lead to statin-related (specifically cerivastatin) rhabdomyolysis rather than inherited rhabdomyolysis. Some susceptibility alleles can be found at low frequencies in population databases.Created: 19 Jan 2022, 5:51 p.m. | Last Modified: 19 Jan 2022, 5:51 p.m.
Panel Version: 0.3
Mode of inheritance
Unknown
Phenotypes
{Drug metabolism, altered, CYP2C8-related}, OMIM:618018; Rhabdomyolysis, cerivastatin-induced
Publications
Tag to_be_confirmed_NHSE tag was added to gene: CYP2C8.
gene: CYP2C8 was added gene: CYP2C8 was added to Acute rhabdomyolysis. Sources: Expert Review Red,NHS GMS Mode of inheritance for gene: CYP2C8 was set to Unknown Publications for gene: CYP2C8 were set to 20739906; 15365880 Phenotypes for gene: CYP2C8 were set to Rhabdomyolysis, cerivastatin-induced; {Drug metabolism, altered, CYP2C8-related}, OMIM:618018