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Newborns main panel

Gene: ZNFX1

Green List (high evidence)
ZNFX1 (zinc finger NFX1-type containing 1)
EnsemblGeneIds (GRCh38): ENSG00000124201
EnsemblGeneIds (GRCh37): ENSG00000124201
ZNFX1 is in 3 panels

1 review

Arina Puzriakova (Genomics England Curator)

The mechanism of pathogenicity is loss-of-function (LOF)
Created: 31 Dec 2025, 2:36 p.m. | Last Modified: 31 Dec 2025, 2:36 p.m.
Panel Version: 0.499
PMID: 33876776 - 2 families PMID: 33872655 - 8 families PMID: 34708404 - 7 families
Created: 31 Dec 2025, 2:28 p.m. | Last Modified: 31 Dec 2025, 2:28 p.m.
Panel Version: 0.498
Created: 31 Dec 2025, 2:28 p.m.
Last Modified: 31 Dec 2025, 2:28 p.m.
Panel version: 0.499

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
Phenotypes
  • Immunodeficiency 91 and hyperinflammation
Clinvar variants
Variants in ZNFX1
Penetrance
None
Panels with this gene

History Filter Activity

31 Dec 2025, Gel status: 3

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Arina Puzriakova (Genomics England Curator)

gene: ZNFX1 was added gene: ZNFX1 was added to Newborns main panel. Sources: Expert Review Green Mode of inheritance for gene: ZNFX1 was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: ZNFX1 were set to Immunodeficiency 91 and hyperinflammation