Brugada syndrome

Gene: DLG1

Red List (low evidence)

DLG1 (discs large MAGUK scaffold protein 1)
EnsemblGeneIds (GRCh38): ENSG00000075711
EnsemblGeneIds (GRCh37): ENSG00000075711
OMIM: 601014, Gene2Phenotype
DLG1 is in 5 panels

3 reviews

Rebecca Whittington (South West GLH)

Red List (low evidence)

No links to phenotypes on OMIM
Created: 25 Mar 2019, 4:30 p.m.
No strong evidence for this gene
Created: 25 Mar 2019, 4:27 p.m.

Mode of inheritance
Unknown

Caroline Wright (Genomics England Curator)

Comment when marking as ready: Not on Manchester diagnostic panel
Created: 11 Feb 2016, 12:22 p.m.

Oxford Medical Genetics Laboratory (OUH NHS Foundation Trust)

Red List (low evidence)

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Red
  • South West GLH
Phenotypes
  • Brugada syndrome, MONDO:0015263
OMIM
601014
Clinvar variants
Variants in DLG1
Penetrance
Complete
Panels with this gene

History Filter Activity

2 Mar 2021, Gel status: 1

Set Phenotypes

Ivone Leong (Genomics England Curator)

Phenotypes for gene: DLG1 were changed from to Brugada syndrome, MONDO:0015263

27 Feb 2019, Gel status: 1

Entity classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

Gene: dlg1 has been classified as Red List (Low Evidence).

21 Feb 2019, Gel status: 0

Added New Source, Set mode of inheritance, Status Update

Ellen McDonagh (Genomics England Curator)

Source South West GLH was added to DLG1. Mode of inheritance for gene DLG1 was changed from to Unknown Rating Changed from Red List (low evidence) to No List (delete)

11 Feb 2016, Gel status: 0

Approved Gene

Caroline Wright (Genomics England Curator)

This proposed gene was validated and added to this panel

11 Feb 2016, Gel status: 0

Gene classified by Genomics England curator

Caroline Wright (Genomics England Curator)

This gene has been removed from the panel.

6 Jan 2016, Gel status: 0

Added New Source

Oxford Medical Genetics Laboratory (OUH NHS Foundation Trust)

DLG1 was added to Brugada syndromepanel. Sources: Oxford Medical Genetics Laboratory

6 Jan 2016, Gel status: 0

Created

Oxford Medical Genetics Laboratory (OUH NHS Foundation Trust)

DLG1 was created by OxfordGenetics