Generalised pustular psoriasis
Gene: HLA-C

HLA-C (major histocompatibility complex, class I, C)
EnsemblGeneIds (GRCh38): ENSG00000204525
EnsemblGeneIds (GRCh37): ENSG00000204525
OMIM: 142840, Gene2Phenotype
HLA-C is in 3 panels

1 review

Sarah Leigh (Genomics England Curator)

Comment when marking as ready: Associated with phenotype in OMIM, not in G2P / DD. At least one variant reported
Created: 22 Nov 2016, 4:01 p.m.

Comment on phenotypes: Also associated with {HIV-1 viremia, susceptibility to} 609423
Created: 22 Nov 2016, 3:37 p.m.

Comment on mode of inheritance: OMIM reports this as multifactorial
Created: 22 Nov 2016, 3:36 p.m.

Mode of inheritance
Other

Phenotypes
{Psoriasis susceptibility 1} 177900

Created: 22 Nov 2016, 3:35 p.m.

Panel version: 0.52

Details

Mode of Inheritance

Other - please specifiy in evaluation comments

Sources

Expert Review Red
Other

Phenotypes

{Psoriasis susceptibility 1} 177900

OMIM

142840

Clinvar variants

Variants in HLA-C

Penetrance

Complete

Panels with this gene