1. Panels
  2. Factor XI deficiency
  3. F11
Genes in panel
Prev Next
STRs in panel
Prev Next
Regions in panel
Prev Next

Factor XI deficiency

Gene: F11

Green List (high evidence)
F11 (coagulation factor XI)
EnsemblGeneIds (GRCh38): ENSG00000088926
EnsemblGeneIds (GRCh37): ENSG00000088926
OMIM: 264900, Gene2Phenotype
F11 is in 3 panels

1 review

Achchuthan Shanmugasundram (Genomics England Curator)

Green List (high evidence)

Comment on phenotypes: This gene has been associated with relevant phenotypes in OMIM (MIM #612416) and the OMIM record was last accessed on 18 December 2025.
Created: 18 Dec 2025, 10:42 a.m. | Last Modified: 18 Dec 2025, 10:42 a.m.
Panel Version: 1.2
F11 has been added to the panel for R120 Factor XI deficiency with a green rating as agreed with the NHS Genomic Medicine Service.
Created: 30 Jun 2023, 1:06 p.m. | Last Modified: 30 Jun 2023, 1:06 p.m.
Panel Version: 0.1

Mode of inheritance
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal

Created: 30 Jun 2023, 1:06 p.m.
Last Modified: 30 Jun 2023, 1:06 p.m.
Panel version: 0.1

Details

Mode of Inheritance
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Sources
  • NHS GMS
  • Expert Review Green
Phenotypes
  • Factor XI deficiency, autosomal dominant, OMIM:612416
  • Factor XI deficiency, autosomal recessive, OMIM:612416
  • congenital factor XI deficiency, MONDO:0012897
OMIM
264900
Clinvar variants
Variants in F11
Penetrance
None
Panels with this gene

History Filter Activity

18 Dec 2025, Gel status: 3

Set Phenotypes

Achchuthan Shanmugasundram (Genomics England Curator)

Phenotypes for gene: F11 were changed from to Factor XI deficiency, autosomal dominant, OMIM:612416; Factor XI deficiency, autosomal recessive, OMIM:612416; congenital factor XI deficiency, MONDO:0012897

29 Jun 2023, Gel status: 3

Created, Added New Source, Set mode of inheritance

Achchuthan Shanmugasundram (Genomics England Curator)

gene: F11 was added gene: F11 was added to Factor XI deficiency. Sources: Expert Review Green,NHS GMS Mode of inheritance for gene: F11 was set to BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal