Familial tumours of the nervous system
Gene: LZTR1
LZTR1 (leucine zipper like transcription regulator 1)
EnsemblGeneIds (GRCh38): ENSG00000099949
EnsemblGeneIds (GRCh37): ENSG00000099949
OMIM: 600574, Gene2Phenotype
LZTR1 is in 14 panels
EnsemblGeneIds (GRCh38): ENSG00000099949
EnsemblGeneIds (GRCh37): ENSG00000099949
OMIM: 600574, Gene2Phenotype
LZTR1 is in 14 panels
2 reviews
Achchuthan Shanmugasundram (Genomics England Curator)
Comment on phenotypes: This gene has been associated with MIM #615670 in OMIM and the OMIM record was last accessed on 29 December 2025.Created: 29 Dec 2025, 2:43 p.m. | Last Modified: 29 Dec 2025, 2:44 p.m.
Panel Version: 2.9
Eleanor Williams (Genomics England Curator)
The rating of this gene has been updated to green and the mode of inheritance set to "MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown" following NHS Genomic Medicine Service approval.Created: 11 Oct 2023, 4:35 p.m. | Last Modified: 11 Oct 2023, 4:35 p.m.
Panel Version: 1.3
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
- Sources
-
- NHS GMS
- Expert Review Green
- Phenotypes
-
- {Schwannomatosis-2, susceptibility to}, OMIM:615670
- LZTR1-related schwannomatosis, MONDO:0014299
- OMIM
- 600574
- Clinvar variants
- Variants in LZTR1
- Penetrance
- None
- Panels with this gene
-
- Familial tumours of the nervous system
- Childhood solid tumours
- Familial Tumours Syndromes of the central & peripheral Nervous system
- DDG2P
- Adult solid tumours cancer susceptibility
- RASopathies
- Hypertrophic cardiomyopathy
- Paediatric or syndromic cardiomyopathy
- Fetal anomalies
- Pigmentary skin disorders
- Monogenic short stature
- Fetal hydrops
- Primary lymphoedema
- Intellectual disability
History Filter Activity
29 Dec 2025, Gel status: 3
Set Phenotypes
Achchuthan Shanmugasundram (Genomics England Curator)Phenotypes for gene: LZTR1 were changed from to {Schwannomatosis-2, susceptibility to}, OMIM:615670; LZTR1-related schwannomatosis, MONDO:0014299
11 Oct 2023, Gel status: 3
Created, Added New Source, Set mode of inheritance
Eleanor Williams (Genomics England Curator)gene: LZTR1 was added gene: LZTR1 was added to Familial tumours of the nervous system. Sources: Expert Review Green,NHS GMS Mode of inheritance for gene: LZTR1 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown