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  3. T
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Sarcoma of possible germline origin

Gene: T

Green List (high evidence)
T (T brachyury transcription factor)
EnsemblGeneIds (GRCh38): ENSG00000164458
EnsemblGeneIds (GRCh37): ENSG00000164458
OMIM: 601397, Gene2Phenotype
T is in 7 panels

1 review

Achchuthan Shanmugasundram (Genomics England Curator)

Green List (high evidence)

T has been added to the panel for the clinical indication 'R457 Sarcoma of possible germline origin' with a green rating as agreed with the NHS Genomic Medicine Service.
Created: 26 Jan 2026, 6:28 p.m. | Last Modified: 26 Jan 2026, 6:28 p.m.
Panel Version: 0.4
Duplications in this gene are only relevant for this panel. Hence, 'gene-duplication' tag has been added.
Created: 30 Dec 2025, 2:38 p.m. | Last Modified: 30 Dec 2025, 2:41 p.m.
Panel Version: 0.2
Added new-gene-name tag, new approved HGNC gene symbol is TBXT.
Created: 30 Dec 2025, 2:35 p.m. | Last Modified: 30 Dec 2025, 2:35 p.m.
Panel Version: 0.2
Comment on phenotypes: This gene is also associated with {Neural tube defects, susceptibility to}, OMIM:182940 & Sacral agenesis with vertebral anomalies, OMIM:615709.
Created: 30 Dec 2025, 2:35 p.m. | Last Modified: 30 Dec 2025, 2:35 p.m.
Panel Version: 0.2

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Created: 30 Dec 2025, 2:35 p.m.
Last Modified: 30 Dec 2025, 2:41 p.m.
Panel version: 0.4

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Green
  • NHS GMS
Tags
new-gene-name gene-duplication
OMIM
601397
Clinvar variants
Variants in T
Penetrance
None
Panels with this gene

History Filter Activity

30 Dec 2025, Gel status: 3

Added Tag

Achchuthan Shanmugasundram (Genomics England Curator)

Tag gene-duplication tag was added to gene: T.

30 Dec 2025, Gel status: 3

Added Tag

Achchuthan Shanmugasundram (Genomics England Curator)

Tag new-gene-name tag was added to gene: T.

30 Dec 2025, Gel status: 3

Created, Added New Source, Set mode of inheritance

Achchuthan Shanmugasundram (Genomics England Curator)

gene: T was added gene: T was added to Sarcoma of possible germline origin. Sources: NHS GMS,Expert Review Green Mode of inheritance for gene: T was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown