Childhood interstitial lung disease
Gene: MARS
MARS (methionyl-tRNA synthetase)
EnsemblGeneIds (GRCh38): ENSG00000166986
EnsemblGeneIds (GRCh37): ENSG00000166986
OMIM: 156560, Gene2Phenotype
MARS is in 10 panels
EnsemblGeneIds (GRCh38): ENSG00000166986
EnsemblGeneIds (GRCh37): ENSG00000166986
OMIM: 156560, Gene2Phenotype
MARS is in 10 panels
1 review
Achchuthan Shanmugasundram (Genomics England Curator)
MARS has been added to the panel for the clinical indication 'R462 Childhood interstitial lung disease' with a green rating as agreed with the NHS Genomic Medicine Service.Created: 26 Jan 2026, 6:34 p.m. | Last Modified: 26 Jan 2026, 6:34 p.m.
Panel Version: 0.5
Added new-gene-name tag, new approved HGNC gene symbol for MARS is MARS1.Created: 30 Dec 2025, 7:29 p.m. | Last Modified: 26 Jan 2026, 6:36 p.m.
Panel Version: 0.5
Comment on phenotypes: This gene has been associated with relevant phenotypes in OMIM (MIM #615486) and the OMIM record was last accessed on 30 December 2025.Created: 30 Dec 2025, 7:22 p.m. | Last Modified: 30 Dec 2025, 7:22 p.m.
Panel Version: 0.2
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Interstitial lung and liver disease, OMIM:615486; severe early-onset pulmonary alveolar proteinosis due to MARS deficiency, MONDO:0014206
Details
- Mode of Inheritance
- BIALLELIC, autosomal or pseudoautosomal
- Sources
-
- Expert Review Green
- NHS GMS
- Phenotypes
-
- severe early-onset pulmonary alveolar proteinosis due to MARS deficiency, MONDO:0014206
- Interstitial lung and liver disease, OMIM:615486
- Tags
- OMIM
- 156560
- Clinvar variants
- Variants in MARS
- Penetrance
- None
- Panels with this gene
-
- Xeroderma pigmentosum, Trichothiodystrophy or Cockayne syndrome
- Childhood interstitial lung disease
- Pulmonary fibrosis familial
- Hereditary spastic paraplegia
- Hereditary neuropathy or pain disorder
- Childhood onset hereditary spastic paraplegia
- Adult onset neurodegenerative disorder
- Adult onset hereditary spastic paraplegia
- Hereditary neuropathy
- Adult onset leukodystrophy
History Filter Activity
30 Dec 2025, Gel status: 3
Added Tag
Achchuthan Shanmugasundram (Genomics England Curator)Tag new-gene-name tag was added to gene: MARS.
30 Dec 2025, Gel status: 3
Created, Added New Source, Set mode of inheritance, Set Phenotypes
Achchuthan Shanmugasundram (Genomics England Curator)gene: MARS was added gene: MARS was added to Childhood interstitial lung disease. Sources: NHS GMS,Expert Review Green Mode of inheritance for gene: MARS was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: MARS were set to severe early-onset pulmonary alveolar proteinosis due to MARS deficiency, MONDO:0014206; Interstitial lung and liver disease, OMIM:615486