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Rare syndromic craniosynostosis or isolated multisuture synostosis

Gene: NOG

Red List (low evidence)

NOG (noggin)
EnsemblGeneIds (GRCh38): ENSG00000183691
EnsemblGeneIds (GRCh37): ENSG00000183691
OMIM: 602991, Gene2Phenotype
NOG is in 9 panels

2 reviews

Tracy Lester (Genetics laboratory, Oxford UK)

Red List (low evidence)

NOG inhibits postoperative resynostosis in a mouse suturectomy model (Cooper et al 2009). Duplicated in 2q35 duplication syndrome that is associated with CSS. No specific reports of NOG variants and CSS? On GeneDX CSS panel ; Review on behalf of Tracy Lester and Andrew Wilkie
Created: 5 Mar 2019, 11:33 a.m.

Tarsal-carpal coalition syndrome; Multiple synostosis syndrome; Stapes ankylosis with broad thumb and toes (Teunissen-Cremers syndrome); Symphalangism, proximal,; Brachydactyly type B2.

Eleanor Williams (Genomics England Curator)

I don't know

This gene was part of an initial gene list collated by Tracy Lester, Oxford Medical Genetics Laboratories, Oxford University Hospitals NHS Foundation Trust, February 2019 on behalf of the GMS Musculoskeletal Specialist Group; Gene symbol submitted: NOG; Suggested initial gene rating: red
Created: 5 Mar 2019, 11:21 a.m.


  • Tarsal-carpal coalition syndrome
  • Stapes ankylosis with broad thumb and toes (Teunissen-Cremers syndrome)
  • Brachydactyly type B2
  • Multiple synostosis syndrome
  • Symphalangism, proximal
Clinvar variants
Variants in NOG
Panels with this gene

History Filter Activity

11 May 2019, Gel status: 1

Set Phenotypes

Eleanor Williams (Genomics England Curator)

Added phenotypes Tarsal-carpal coalition syndrome; Stapes ankylosis with broad thumb and toes (Teunissen-Cremers syndrome); Brachydactyly type B2; Multiple synostosis syndrome; Symphalangism, proximal for gene: NOG

5 Mar 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance

Eleanor Williams (Genomics England Curator)

gene: NOG was added gene: NOG was added to Craniosynostosis. Sources: NHS GMS Mode of inheritance for gene: NOG was set to