Kleine-Levin syndromeGene: EIF3G
Narcolepsy associated with rs3826784 (c.596-260A>G) in EIF3G. The disease-associated allele increases EIF3G mRNA expression. EIF3G is located in the narcolepsy risk locus and EIF3G expression correlates with PPAN and P2RY11 expression (from PMID 25669430)
Created: 5 Jan 2017, 9:33 a.m.
Mode of inheritance
Rosa Peraita-Adrados (Sleep and Epilepsy Unit-Clinical Neurophysiology Service. Gregorio Maranon University Hospital. Complutense University of Madrid (UCM).Madrid.Spain.), agrees with the status of the gene on this panel, although she has not reviewed every gene individually
EIF3G was created by sleigh
EIF3G was added to Kleine-Levin syndromepanel. Sources: Literature