Short QT syndromeGene: LRP5
The evidence here comes from animal model of LRP5 knockout, which results in a short QT interval via modulation of calcium channel degradation. So, in principle, this shows a novel modulator of repolarization that could be implicated in SQTS. Yet to be seen patients.
Created: 15 Nov 2018, 5:40 p.m.
Mode of inheritance
Mode of pathogenicity
Jules Hancox: The evidence here comes from a
Publications for gene: LRP5 were set to PMID: 30309679
Gene: lrp5 has been classified as Red List (Low Evidence).
gene: LRP5 was added gene: LRP5 was added to Short QT syndrome. Sources: Literature Mode of inheritance for gene: LRP5 was set to Unknown Publications for gene: LRP5 were set to PMID: 30309679 Phenotypes for gene: LRP5 were set to short qt Mode of pathogenicity for gene: LRP5 was set to Other Review for gene: LRP5 was set to RED