Genomic imprinting

Gene: MCTS2P

I don't know

MCTS2P (PSIMCT-1, MCTS1 pseudogene; referred to as MCTS2 (malignant T cell amplified sequence 2) by Wood et al.) was exclusively expressed from the paternal allele in fetal brain, heart and tongue in one informative fetus, and monoallelically expressed in two additional fetuses (same tissues) (Wood AJ et al, 2007). Mouse Mcts2 is also imprinted and paternally expressed. PSIMCT-1 is reported to be a pseudogene derived from the X chromosome gene MCTS1/Mcts1 (Nandi S et al, 2006). Despite 15 nucleotide differences the 181 aa open reading frame is conserved with 95% identity to MCTS1. Thus Wood et al. believe it to be a functional retrogene. PSIMCT-1 retrotransposed into intron 4 of HM13/H13 of mouse and human. It is absent in the genome of cow and dog.

Created: 22 Dec 2020, 6:10 p.m. | Last Modified: 22 Dec 2020, 6:10 p.m.

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