Genomic imprinting
Gene: MEG3
Not associated with a phenotype in OMIM, Gen2Phen or MONDO. The imprinted gene MEG3 has been associated with multiple cases of Temple syndrome (PMID: 33010492;33746039) and to Kagami-Ogata syndrome (PMID: 33067531).Created: 21 Jan 2022, 8:33 a.m. | Last Modified: 21 Jan 2022, 8:33 a.m.
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PiRNAs (Piwi-interacting RNAs) at 14q32 (DLK1-MEG3(GTL2)) are homologous with several human 14q(I) and 14(II) C/D RNA sequences (PMID 18271756)(http://igc.otago.ac.nz). Circadian expression reported in CircaDB (http://circadb.hogeneschlab.org/human).Created: 22 Dec 2020, 6:10 p.m. | Last Modified: 22 Dec 2020, 6:10 p.m.
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Publications
Phenotypes for gene: MEG3 were changed from Kagami-Ogata syndrome, OMIM:608149; Temple syndrome, OMIM:616222 to Temple syndrome, OMIM:616222; Kagami-Ogata syndrome, OMIM:608149
Publications for gene: MEG3 were set to 30794780; 18271756; http://igc.otago.ac.nz/home.html; 29641995
Gene: meg3 has been classified as Green List (High Evidence).
Phenotypes for gene: MEG3 were changed from to Kagami-Ogata syndrome, OMIM:608149; Temple syndrome, OMIM:616222
Publications for gene: MEG3 were set to 30794780; 18271756; http://igc.otago.ac.nz/home.html
gene: MEG3 was added gene: MEG3 was added to Imprinted Genes. Sources: Literature Mode of inheritance for gene: MEG3 was set to MONOALLELIC, autosomal or pseudoautosomal, paternally imprinted (maternal allele expressed) Publications for gene: MEG3 were set to 30794780; 18271756; http://igc.otago.ac.nz/home.html