Familial hidradenitis suppurativa
Gene: TNF
TNF (tumor necrosis factor)
EnsemblGeneIds (GRCh38): ENSG00000232810
EnsemblGeneIds (GRCh37): ENSG00000232810
OMIM: 191160, Gene2Phenotype
TNF is in 3 panels
EnsemblGeneIds (GRCh38): ENSG00000232810
EnsemblGeneIds (GRCh37): ENSG00000232810
OMIM: 191160, Gene2Phenotype
TNF is in 3 panels
2 reviews
John McGrath (KCL)
Rebecca Foulger (Genomics England curator)
Comment on list classification: Kept rating as red based on expert review, and insufficient evidence for disease causation.Created: 6 Jul 2017, 2:17 p.m.
SNP analysis in PMID:23106544 reports that TNF gene polymorphism in the promoter regions (-238) was associated with a predisposition to hidradenitis suppurativa (HS). Added 'promoter' tag to highlight this information.Created: 19 Jun 2017, 10:34 a.m.
Mode of inheritance
Unknown
Phenotypes
predisposition to hidradenitis suppurativa
Publications
Details
- Mode of Inheritance
- Unknown
- Sources
-
- Expert Review Red
- Literature
- Phenotypes
-
- predisposition to hidradenitis suppurativa
- Tags
- OMIM
- 191160
- Clinvar variants
- Variants in TNF
- Penetrance
- Complete
- Publications
- Panels with this gene
History Filter Activity
6 Jul 2017, Gel status: 1
panel promoted to version 1
Rebecca Foulger (Genomics England curator)6th July 2017: Revised panel and promoted to Version 1.0 based on expert review. Although PSENEN, NCSTN and PSEN1 (all green genes on this panel) collectively only account for approximately 7% of all hidradenitis suppurativa (HS), there is insufficient evidence to promote any further genes to green at this time.
6 Jul 2017, Gel status: 1
Gene classified by Genomics England curator
Rebecca Foulger (Genomics England curator)This gene has been classified as Red List (Low Evidence).
19 Jun 2017, Gel status: 0
Created
Rebecca Foulger (Genomics England curator)TNF was created by rfoulger
19 Jun 2017, Gel status: 0
Added New Source
Rebecca Foulger (Genomics England curator)TNF was added to Familial hidradenitis suppurativapanel. Sources: Literature