Hyperthyroidism

Gene: TRU-TCA1-1

Ensembl identifiers not available for GRCh37 (release 82) or GRCh38 (release 90)

Created: 8 Jul 2020, 2:48 p.m. | Last Modified: 8 Jul 2020, 2:48 p.m.

Panel Version: 2.6

Red List (low evidence)

At present we offer THRA, SECISBP2 and TRNAU1 sequencing on a research basis to clinicians who refer cases fulfilling the clinical and biochemical criteria that you indicate.

Krishna Chatterjee
Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge

Created: 15 Mar 2017, 4:51 p.m.

Report variants in this gene as part of diagnostic practice : Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge (From expert review Krishna Chatterjee and Carla Moran)

Created: 15 Mar 2017, 4:50 p.m.

Comment when marking as ready: gene has been assessed for involvement in Resistance to thyroid hormone according to expert reviews and further curation

Created: 15 Mar 2017, 3:48 p.m.

Comment on list classification: Note on Red Rating: because this gene encodes transfer RNA it currently can only be given Red gene status in PanelApp as we currently only use protein-coding and mitochondrial genes for tiering.

Created: 15 Mar 2017, 3:29 p.m.

Note that official gene symbol TRU-TCA1-1 was previously TRNAU1 (and can be still referred to in the literature with the synonym as TRNASEC).

Created: 14 Mar 2017, 4:35 p.m.

Added tag locus-type-rna-transfer to explain why there is no Ensembl gene ID for this entity

Created: 4 Mar 2017, 7:22 p.m.

Mode of inheritance
Other

Variants in this GENE are reported as part of current diagnostic practice