Hyperthyroidism
Gene: TRU-TCA1-1Ensembl identifiers not available for GRCh37 (release 82) or GRCh38 (release 90)Created: 8 Jul 2020, 2:48 p.m. | Last Modified: 8 Jul 2020, 2:48 p.m.
Panel Version: 2.6
At present we offer THRA, SECISBP2 and TRNAU1 sequencing on a research basis to clinicians who refer cases fulfilling the clinical and biochemical criteria that you indicate.
Krishna Chatterjee
Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge
Created: 15 Mar 2017, 4:51 p.m.
Report variants in this gene as part of diagnostic practice : Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge (From expert review Krishna Chatterjee and Carla Moran)Created: 15 Mar 2017, 4:50 p.m.
Comment when marking as ready: gene has been assessed for involvement in Resistance to thyroid hormone according to expert reviews and further curationCreated: 15 Mar 2017, 3:48 p.m.
Comment on list classification: Note on Red Rating: because this gene encodes transfer RNA it currently can only be given Red gene status in PanelApp as we currently only use protein-coding and mitochondrial genes for tiering.Created: 15 Mar 2017, 3:29 p.m.
Note that official gene symbol TRU-TCA1-1 was previously TRNAU1 (and can be still referred to in the literature with the synonym as TRNASEC).Created: 14 Mar 2017, 4:35 p.m.
Added tag locus-type-rna-transfer to explain why there is no Ensembl gene ID for this entityCreated: 4 Mar 2017, 7:22 p.m.
Mode of inheritance
Other
Variants in this GENE are reported as part of current diagnostic practice
Tag ensembl_ids_known_missing tag was added to gene: TRU-TCA1-1.
Panel reviews were assessed, and panel was revised according to expert reviews and further curation
This gene has been classified as Red List (Low Evidence).
This gene has been classified as Red List (Low Evidence).
TRU-TCA1-1 was added to Resistance to thyroid hormonepanel. Sources: Eligibility statement prior genetic testing
TRU-TCA1-1 was added to Resistance to thyroid hormonepanel. Sources: Expert list
TRU-TCA1-1 was created by LouiseD