Severe familial anorexia
Gene: BDNF

BDNF (brain derived neurotrophic factor)
EnsemblGeneIds (GRCh38): ENSG00000176697
EnsemblGeneIds (GRCh37): ENSG00000176697
OMIM: 113505, Gene2Phenotype
BDNF is in 7 panels

1 review

Gerome Breen (King's College London)

There is to my knowledge no evidence linking mutations in BDNF with anorexia nervosa.

I co-chair the PGC Anorexia genetics consortium.
Created: 21 Dec 2015, 1:50 p.m.

Created: 21 Dec 2015, 1:50 p.m.

Panel version: 0.0

Details

Sources

Radboud University Medical Center, Nijmegen

Phenotypes

{Memory impairment, susceptibility to}Central hypoventilation syndrome, congenital, 209880{Obsessive-compulsive disorder, protection against}, 164230{Bulimia nervosa, age of onset of weight loss in},607499{Anorexia nervosa, susceptibi

OMIM

113505

Clinvar variants

Variants in BDNF

Penetrance

Complete

Publications

15657604

Mode of Pathogenicity

gain-of-function

Panels with this gene

History Filter Activity

14 Dec 2016, Gel status: 1

panel promoted to version 1

Ellen McDonagh (Genomics England Curator)

14/Dec/2016: Discussed with expert and internally - there are no genes suitable to be green for this disorder.

11 May 2015, Gel status: 1

Added New Source

Eik Haraldsdottir (Genomics England)

BDNF was added to severe familial anorexiapanel. Sources: Radboud University Medical Center, Nijmegen

Severe familial anorexia Gene: BDNF