Growth failure in early childhood
Gene: IGF2Comment on phenotypes: Previous phenotypes (overwritten): SRS;IUGR;Pre- and post-natal growth failure;?Growth restriction, severe, with distinctive facies, 616489;Silver-Russell phenptypeCreated: 26 Mar 2024, 3:54 p.m. | Last Modified: 26 Mar 2024, 3:54 p.m.
Panel Version: 3.33
As a result of watchlist tag audit the watchlist tag was removed from IGF2- this is now a green gene with sufficient evidence/reviewCreated: 13 Jan 2020, 1:58 p.m. | Last Modified: 13 Jan 2020, 1:58 p.m.
Panel Version: 1.3
Following discussion with members of the Endocrine Specialist Group at the Webex call on 23.05.19, it was agreed that IGF2 should be included on the panel. Therefore updated rating from Red to Green.Created: 30 May 2019, 9:34 a.m.
This gene is part of a consensus list for SRS/SRS-like testing provided by Frederic Brioude. Suggested initial gene rating: Green; Evidence for inclusion: none given; Evidence for exclusion: none given; Technical notes (e.g. non-coding/CNV mutations requiring coverage?): none given; Phenotypes: SRS.Created: 14 May 2019, 1:25 p.m.
Phenotypes
SRS
Phenotypes for gene: IGF2 were changed from SRS; IUGR; Pre- and post-natal growth failure; ?Growth restriction, severe, with distinctive facies, 616489; Silver-Russell phenptype to Silver-Russell syndrome 3, OMIM:616489
Tag watchlist was removed from gene: IGF2.
Source Expert Review Green was added to IGF2. Rating Changed from Red List (low evidence) to Green List (high evidence)
Source Expert list was added to IGF2. Added phenotypes SRS for gene: IGF2
Phenotypes for gene: IGF2 were changed from Silver-Russell phenptype; IUGR; Pre- and post-natal growth failure to Silver-Russell phenptype; IUGR; Pre- and post-natal growth failure; ?Growth restriction, severe, with distinctive facies, 616489
Tag watchlist tag was added to gene: IGF2.
gene: IGF2 was added gene: IGF2 was added to Growth failure in early childhood. Sources: Expert Review Red Mode of inheritance for gene: IGF2 was set to MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed) Publications for gene: IGF2 were set to 26154720 Phenotypes for gene: IGF2 were set to Silver-Russell phenptype; IUGR; Pre- and post-natal growth failure