1. Panels
  2. Renal and urinary tract disorders
  3. ROBO2
STRs in panel
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Renal and urinary tract disorders

Gene: ROBO2

Red List (low evidence)
ROBO2 (roundabout guidance receptor 2)
EnsemblGeneIds (GRCh38): ENSG00000185008
EnsemblGeneIds (GRCh37): ENSG00000185008
OMIM: 602431, Gene2Phenotype
ROBO2 is in 4 panels

4 reviews

Helen Stuart (University of Manchester)

Red List (low evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Created: 5 Nov 2017, 2:37 a.m.

Panel version: Imported from CAKUT panel version 0

Bill Newman (Manchester Centre for Genomic Medicine)

Red List (low evidence)

Created: 5 Nov 2017, 2:37 a.m.

Panel version: Imported from CAKUT panel version 0

Adrian Woolf (Professor of Paediatric Scicence, Univerisity of Manchester)

Red List (low evidence)

Several papers show association of vesicoureteric reflux with heterozygous ROBO2 polymorphisms but other studies do not. On the other hand, good evidence that biallelic mutations cause major renal tract malformations in mice.
Created: 22 Apr 2016, 11:39 a.m.

Mode of inheritance
Unknown

Created: 22 Apr 2016, 11:39 a.m.

Panel version: Imported from CAKUT panel version 0.85

Ellen McDonagh (Genomics England Curator)

Comment on list classification: Demoted from amber to red as two reviewers in agreement.
Created: 29 Mar 2016, 10:33 a.m.
Created: 29 Mar 2016, 10:33 a.m.

Panel version: Imported from CAKUT panel version 0.22

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Red
Phenotypes
  • Vesicoureteral reflux 2, 610878
  • Vesicoureteral Reflux
OMIM
602431
Clinvar variants
Variants in ROBO2
Penetrance
None
Panels with this gene

History Filter Activity

30 Jan 2019, Gel status: 1

Panel promoted to version 1.0

Eleanor Williams (Genomics England Curator)

Ellen McDonagh: Comment on list classification

20 Dec 2018, Gel status: 1

Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Added phenotypes Vesicoureteral reflux 2, 610878; Vesicoureteral Reflux for gene: ROBO2

20 Dec 2018, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: ROBO2 was added gene: ROBO2 was added to Renal and urinary tract disorders. Sources: Expert Review Red Mode of inheritance for gene: ROBO2 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Phenotypes for gene: ROBO2 were set to Vesicoureteral reflux 2, 610878; Vesicoureteral Reflux