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  2. Respiratory ciliopathies including non-CF bronchiectasis
  3. HYDIN
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Respiratory ciliopathies including non-CF bronchiectasis

Gene: HYDIN

Green List (high evidence)
HYDIN (HYDIN, axonemal central pair apparatus protein)
EnsemblGeneIds (GRCh38): ENSG00000157423
EnsemblGeneIds (GRCh37): ENSG00000157423
OMIM: 610812, Gene2Phenotype
HYDIN is in 9 panels

4 reviews

Louise Daugherty (Genomics England Curator)

Green List (high evidence)

Initial gene list and info collated by Ian Berry Leeds Genetics Laboratory November 2018 on behalf of the GMS Respiratory specialist test group. Gene Symbol submitted: HYDIN; Suggested initial gene rating: Green; Evidence for inclusion: OMIM PCD gene or intersection of >2 panels; Evidence for exclusion: none given; Technical notes (e.g. non-coding/CNV mutations requiring coverage?): Highly similar pseudogene.
Created: 5 Dec 2018, 1:54 p.m.
Created: 5 Dec 2018, 1:54 p.m.

Panel version: 0.2

Ian Berry (Leeds Genetics Laboratory)

Green List (high evidence)

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Ciliary dyskinesia, primary, 5, 608647

Variants in this GENE are reported as part of current diagnostic practice

Created: 5 Nov 2017, 2:39 a.m.

Panel version: Imported from Primary ciliary disorders panel version 0

Caroline Wright (Genomics England Curator)

Comment on list classification: 2 expert reviewers agree and current diagnostic
Created: 10 May 2016, 9:03 a.m.
Created: 10 May 2016, 9:03 a.m.

Panel version: Imported from Primary ciliary disorders panel version 0.10

Hannah Mitchison (UCL and GOSH)

Green List (high evidence)

UK mutations reported. Note that HYDIN2 on Chr1 is an almost identical copy gene that can cause confusion for diagnostics (Olbrich etal. Am. J. Hum. Genet. 91: 672-684, 2012)
Created: 8 Dec 2015, 4:25 p.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Ciliary dyskinesia, primary, 5

Publications

Variants in this GENE are reported as part of current diagnostic practice

Created: 8 Dec 2015, 4:25 p.m.

Panel version: Imported from Primary ciliary disorders panel version 0

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • NHS GMS
Phenotypes
  • Ciliary dyskinesia, primary, 5, OMIM:608647
OMIM
610812
Clinvar variants
Variants in HYDIN
Penetrance
None
Publications
Panels with this gene

History Filter Activity

12 Aug 2025, Gel status: 3

Set publications

Arina Puzriakova (Genomics England Curator)

Publications for gene: HYDIN were set to

12 Aug 2025, Gel status: 3

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Phenotypes for gene: HYDIN were changed from Ciliary dyskinesia, primary, 5, 608647 to Ciliary dyskinesia, primary, 5, OMIM:608647

17 Jan 2019, Gel status: 4

Set mode of inheritance, Set Phenotypes

Louise Daugherty (Genomics England Curator)

Mode of inheritance for gene HYDIN was changed from to BIALLELIC, autosomal or pseudoautosomal Added phenotypes Ciliary dyskinesia, primary, 5, 608647 for gene: HYDIN

5 Dec 2018, Gel status: 3

Added New Source, Status Update

Louise Daugherty (Genomics England Curator)

Source Expert Review Green was added to HYDIN. Rating Changed from Red List (low evidence) to Green List (high evidence)

5 Dec 2018, Gel status: 1

Created, Added New Source, Set mode of inheritance

Louise Daugherty (Genomics England Curator)

gene: HYDIN was added gene: HYDIN was added to Respiratory ciliopathies including non-CF bronchiectasis. Sources: NHS GMS Mode of inheritance for gene: HYDIN was set to