Ectodermal dysplasia
Gene: HLA-DRA

HLA-DRA (major histocompatibility complex, class II, DR alpha)
EnsemblGeneIds (GRCh38): ENSG00000204287
EnsemblGeneIds (GRCh37): ENSG00000204287
OMIM: 142860, Gene2Phenotype
HLA-DRA is in 3 panels

2 reviews

John McGrath (KCL)

I don't know

This has been associated with a form of scarring alopecia in one Indian family but with no fine mapping of the locus. Amber because of the single family reports and only component features of other syndromes.
Created: 22 Jun 2017, 2:59 p.m.

Created: 22 Jun 2017, 2:59 p.m.

Panel version: Imported from Familial cicatricial alopecia panel version 0.8

Rebecca Foulger (Genomics England curator)

Comment on list classification: Updated rating from Red to Amber to match expert review.
Created: 13 Jul 2017, 1:30 p.m.

Orphanet used as source for HLA-DRA and Graham Little syndrome- a subtype of lichen planopilaris characterized by symptoms including progressive cicatricial (scarring) alopecia.
Created: 22 Nov 2016, 5:12 p.m.

Created: 22 Nov 2016, 5:12 p.m.

Panel version: Imported from Familial cicatricial alopecia panel version 0.5

Details

Mode of Inheritance

Unknown

Sources

Expert Review Amber

Phenotypes

lichen planopilaris
progressive cicatricial (scarring) alopecia
Graham Little syndrome
Graham Little-Piccardi-Lassueur syndrome

OMIM

142860

Clinvar variants

Variants in HLA-DRA

Penetrance

None

Panels with this gene

History Filter Activity

3 Jan 2019, Gel status: 2

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: HLA-DRA was added gene: HLA-DRA was added to Ectodermal dysplasia. Sources: Expert Review Amber Mode of inheritance for gene: HLA-DRA was set to Unknown Phenotypes for gene: HLA-DRA were set to lichen planopilaris; progressive cicatricial (scarring) alopecia; Graham Little syndrome; Graham Little-Piccardi-Lassueur syndrome

Ectodermal dysplasia Gene: HLA-DRA