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  2. Ectodermal dysplasia
  3. WNT10A
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Ectodermal dysplasia

Gene: WNT10A

Green List (high evidence)
WNT10A (Wnt family member 10A)
EnsemblGeneIds (GRCh38): ENSG00000135925
EnsemblGeneIds (GRCh37): ENSG00000135925
OMIM: 606268, Gene2Phenotype
WNT10A is in 2 panels

2 reviews

John McGrath (King's College London)

Green List (high evidence)

Phenotypes
Hypohidrotic ectodermal dysplasia; Schopf-Schulz-Passarge syndrome

Created: 5 Nov 2017, 2:37 a.m.

Panel version: Imported from Ectodermal dysplasia without a known gene mutation panel version 0

Sarah Leigh (Genomics England Curator)

Comment when marking as ready: Associated with phenotypes in OMIM, not in G2P. Numerous variants reported in Odontoonychodermal dysplasia 257980
Created: 10 Aug 2016, 11:20 a.m.
Comment on phenotypes: Also associated with Tooth agenesis, selective, 4 150400 (monoallelic)
Created: 10 Aug 2016, 11:19 a.m.
Created: 10 Aug 2016, 11:19 a.m.

Panel version: Imported from Ectodermal dysplasia without a known gene mutation panel version 0.118

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
Phenotypes
  • Schopf-Schulz-Passarge syndrome, OMIM:224750
  • Odontoonychodermal dysplasia, OMIM:257980
OMIM
606268
Clinvar variants
Variants in WNT10A
Penetrance
None
Panels with this gene

History Filter Activity

22 Jul 2021, Gel status: 3

Set Phenotypes

Ivone Leong (Genomics England Curator)

Phenotypes for gene: WNT10A were changed from Schopf-Schulz-Passarge syndrome, OMIM:224750; Odontoonychodermal dysplasia, OMIM:257980 to Schopf-Schulz-Passarge syndrome, OMIM:224750; Odontoonychodermal dysplasia, OMIM:257980

22 Jul 2021, Gel status: 3

Set Phenotypes

Ivone Leong (Genomics England Curator)

Phenotypes for gene: WNT10A were changed from Schopf-Schulz-Passarge syndrome 224750; Odontoonychodermal dysplasia 257980 to Schopf-Schulz-Passarge syndrome, OMIM:224750; Odontoonychodermal dysplasia, OMIM:257980

3 Jan 2019, Gel status: 4

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: WNT10A was added gene: WNT10A was added to Ectodermal dysplasia. Sources: Expert Review Green Mode of inheritance for gene: WNT10A was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: WNT10A were set to Schopf-Schulz-Passarge syndrome 224750; Odontoonychodermal dysplasia 257980