Primary lymphoedemaGene: FLT4
This gene was part of an initial gene list collated by Matthew Edwards Royal Brompton Hospital sent 16th Jan 2019 on behalf of the London South GLH for review by the GMS Cardiology Specialist Group. Only gene symbol from the Royal Brompton gene panel was provided - suggested initial gene rating and evidence for inclusion not provided with the list.
Created: 20 Feb 2019, 2:17 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Primary lymphoedema; Milroy disease
Comment on phenotypes: Previously known as Milroy disease.
Created: 19 Jun 2019, 3:24 p.m.
Comment on phenotypes: Also associated with Hemangioma, capillary infantile, somatic 602089
Created: 8 Aug 2016, 8:40 a.m.
Phenotypes for gene: FLT4 were changed from Lymphedema, hereditary, IA 153100 to Lymphedema, hereditary, IA 153100
Source London South GLH was added to FLT4. Rating Changed from Green List (high evidence) to Green List (high evidence)
FLT4 was added to Lymphatic Disorderspanel. Sources: Eligibility statement prior genetic testing
A combined panel for lymphatic disorders - Meiges disease - Milroy disease - Lymphoedema distichiasis Promoted to V1 02/11/2016
FLT4 was created by sleigh
FLT4 was added to Lymphatic Disorderspanel. Sources: Radboud University Medical Center, Nijmegen,UKGTN,Expert Review Green