Primary lymphoedema

Gene: FLT4

Green List (high evidence)

FLT4 (fms related tyrosine kinase 4)
EnsemblGeneIds (GRCh38): ENSG00000037280
EnsemblGeneIds (GRCh37): ENSG00000037280
OMIM: 136352, Gene2Phenotype
FLT4 is in 11 panels

3 reviews

Ellen McDonagh (Genomics England Curator)

I don't know

This gene was part of an initial gene list collated by Matthew Edwards Royal Brompton Hospital sent 16th Jan 2019 on behalf of the London South GLH for review by the GMS Cardiology Specialist Group. Only gene symbol from the Royal Brompton gene panel was provided - suggested initial gene rating and evidence for inclusion not provided with the list.
Created: 20 Feb 2019, 2:17 p.m.

Pia Ostergaard (St George's)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Primary lymphoedema; Milroy disease


Sarah Leigh (Genomics England Curator)

Comment on phenotypes: Previously known as Milroy disease.
Created: 19 Jun 2019, 3:24 p.m.
Comment on phenotypes: Also associated with Hemangioma, capillary infantile, somatic 602089
Created: 8 Aug 2016, 8:40 a.m.


Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
  • London South GLH
  • Eligibility statement prior genetic testing
  • Radboud University Medical Center, Nijmegen
  • Expert Review Green
  • Lymphedema, hereditary, IA 153100
Clinvar variants
Variants in FLT4
Panels with this gene

History Filter Activity

19 Jun 2019, Gel status: 4

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for gene: FLT4 were changed from Lymphedema, hereditary, IA 153100 to Lymphedema, hereditary, IA 153100

20 Feb 2019, Gel status: 3

Added New Source, Status Update

Ellen McDonagh (Genomics England Curator)

Source London South GLH was added to FLT4. Rating Changed from Green List (high evidence) to Green List (high evidence)

17 Feb 2017, Gel status: 4

Upload gene information

Ellen McDonagh (Genomics England Curator)

FLT4 was added to Lymphatic Disorderspanel. Sources: Eligibility statement prior genetic testing

2 Nov 2016, Gel status: 4

panel promoted to version 1

Sarah Leigh (Genomics England Curator)

A combined panel for lymphatic disorders - Meiges disease - Milroy disease - Lymphoedema distichiasis Promoted to V1 02/11/2016

30 Sep 2016, Gel status: 0


Sarah Leigh (Genomics England Curator)

FLT4 was created by sleigh

30 Sep 2016, Gel status: 4

Added New Source

Sarah Leigh (Genomics England Curator)

FLT4 was added to Lymphatic Disorderspanel. Sources: Radboud University Medical Center, Nijmegen,UKGTN,Expert Review Green