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  3. SGCD
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Dilated and arrhythmogenic cardiomyopathy

Gene: SGCD

Amber List (moderate evidence)
SGCD (sarcoglycan delta)
EnsemblGeneIds (GRCh38): ENSG00000170624
EnsemblGeneIds (GRCh37): ENSG00000170624
OMIM: 601411, Gene2Phenotype
SGCD is in 8 panels

7 reviews

Ida Ertmanska (Genomics England Curator)

The gene-disease relationship between SGCD and dilated cardiomyopathy has been classified as No Known Disease Relationship by ClinGen (Dilated Cardiomyopathy GCEP, March 2025).
Created: 13 Jan 2026, 4:09 p.m. | Last Modified: 13 Jan 2026, 4:09 p.m.
Panel Version: 3.10
Created: 13 Jan 2026, 4:09 p.m.
Last Modified: 13 Jan 2026, 4:09 p.m.
Panel version: 3.10

Ivone Leong (Genomics England Curator)

I don't know

Submitted on behalf of the GMS Cardiology specialist group. The group has agreed that this gene should be Amber on this panel.
Created: 3 Dec 2019, 2:28 p.m. | Last Modified: 3 Dec 2019, 2:28 p.m.
Panel Version: 0.52
Created: 3 Dec 2019, 2:28 p.m.
Last Modified: 3 Dec 2019, 2:28 p.m.
Panel version: 0.52

Rebecca Whittington (South West GLH)

Green List (high evidence)

Cardiomyopathy, dilated, 1L OMIM#606685; Muscular dystrophy, limb-girdle, autosomal recessive 6 OMIM#601287
Created: 25 Mar 2019, 4:30 p.m.
HGMD: 6 variants all but one ?DM, though a number listed in Walsh through LMM and classified as LP. Included in review of DCM genes: Dalin 2017 International Journal of Cardiology 228 (2017) 742748 (no variants though), Hershberger 2013 Nat Rev Cardiol 10:531.
Created: 25 Mar 2019, 4:27 p.m.

Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Variants in this GENE are reported as part of current diagnostic practice

Created: 25 Mar 2019, 4:24 p.m.

Panel version: Imported from Dilated Cardiomyopathy and conduction defects panel version 1.55

Ellen McDonagh (Genomics England Curator)

I don't know

Comment on list classification: This gene appears on 4/4 gene lists submitted from GLHs, however has Red/Amber reviews from these labs and therefore demoted to Amber for further discussion.
Created: 24 Mar 2019, 10:24 a.m.
This gene was part of an initial gene list collated by Matthew Edwards Royal Brompton Hospital sent 16th Jan 2019 on behalf of the London South GLH for review by the GMS Cardiology Specialist Group. Only gene symbol from the Royal Brompton gene panel was provided - suggested initial gene rating and evidence for inclusion not provided with the list.
Created: 20 Feb 2019, 2:17 p.m.
Created: 20 Feb 2019, 2:17 p.m.

Panel version: Imported from Dilated cardiomyopathy - teen and adult panel version 1.46

James Eden (Manchester)

Red List (low evidence)

Gene currently tested on Manchester cardiac gene panel. Only class 1-3 variants detected to date. 36 variants listed on HGMD (accessed 29/01/2019). ClinGen Knowledge Base: gene not curated (accessed 29/01/2019).
Created: 14 Feb 2019, 1:38 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Cardiomyopathy, dilated, 1L (606685); Muscular dystrophy, limb-girdle, autosomal recessive 6 (601287)

Publications

Variants in this GENE are reported as part of current diagnostic practice

Created: 14 Feb 2019, 1:38 p.m.

Panel version: Imported from Dilated cardiomyopathy - teen and adult panel version 1.44

Caroline Wright (Genomics England Curator)

Comment when marking as ready: On Manchester diagnostic panel
Created: 14 Feb 2016, 4:21 p.m.
Created: 14 Feb 2016, 4:21 p.m.

Panel version: Imported from Dilated cardiomyopathy - teen and adult panel version 0.5

Oxford Medical Genetics Laboratory (OUH NHS Foundation Trust)

I don't know

Not fully reviewed. Would be interested to hear findings of Manchester laboratory testing this gene in DCM cohorts.
Created: 17 Jan 2019, 5:41 p.m.
Created: 6 Jan 2016, 5:12 p.m.

Panel version: Imported from Dilated cardiomyopathy - teen and adult panel version 1.40

Details

Mode of Inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
  • UKGTN
  • South West GLH
  • Radboud University Medical Center, Nijmegen
  • Wessex and West Midlands GLH
  • Illumina TruGenome Clinical Sequencing Services
  • London South GLH
  • North West GLH
  • Expert list
  • Emory Genetics Laboratory
  • South West GLH
  • London South GLH
  • North West GLH
  • Wessex and West Midlands GLH
Phenotypes
  • Muscular dystrophy, limb-girdle, autosomal recessive 6 (601287)
  • Cardiomyopathy, dilated, 1L
  • Cardiomyopathy, dilated, 1L (606685)
OMIM
601411
Clinvar variants
Variants in SGCD
Penetrance
None
Publications
Panels with this gene

History Filter Activity

13 Jan 2026, Gel status: 2

Removed Tag

Ida Ertmanska (Genomics England Curator)

Tag disputed was removed from gene: SGCD.

13 Jan 2026, Gel status: 2

Added Tag

Ida Ertmanska (Genomics England Curator)

Tag disputed tag was added to gene: SGCD.

24 Mar 2019, Gel status: 2

Entity classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

Gene: sgcd has been classified as Amber List (Moderate Evidence).

8 Mar 2019, Gel status: 4

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: SGCD was added gene: SGCD was added to Dilated cardiomyopathy - adult and teen. Sources: Emory Genetics Laboratory,Expert list,North West GLH,Expert Review Green,London South GLH,Illumina TruGenome Clinical Sequencing Services,Wessex and West Midlands GLH,Radboud University Medical Center, Nijmegen,South West GLH,UKGTN Mode of inheritance for gene: SGCD was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal Publications for gene: SGCD were set to 19259135; 20186049; 27532257 Phenotypes for gene: SGCD were set to Muscular dystrophy, limb-girdle, autosomal recessive 6 (601287); Cardiomyopathy, dilated, 1L; Cardiomyopathy, dilated, 1L (606685)