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Thoracic aortic aneurysm or dissection (GMS) v1.23 FOXE3 Ivone Leong Tag for-review was removed from gene: FOXE3.
Thoracic aortic aneurysm or dissection (GMS) v1.23 FOXE3 Ivone Leong commented on gene: FOXE3: The rating of this gene has been updated following NHS Genomic Medicine Service approval.
Thoracic aortic aneurysm or dissection (GMS) v1.22 FOXE3 Ivone Leong Source Expert Review Amber was added to FOXE3.
Rating Changed from Green List (high evidence) to Amber List (moderate evidence)
Thoracic aortic aneurysm or dissection (GMS) v1.16 FOXE3 Eleanor Williams Added comment: Comment on mode of inheritance: All cases reported in PMID: 26854927 (Kuang et al 2016) are heterozygous so the MONOALLELIC mode of inheritance is appropriate for the Thoracic aortic aneurysms and acute aortic dissection phenotype.
Thoracic aortic aneurysm or dissection (GMS) v1.16 FOXE3 Eleanor Williams Mode of inheritance for gene: FOXE3 was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Thoracic aortic aneurysm or dissection (GMS) v1.3 FOXE3 Ivone Leong Tag for-review tag was added to gene: FOXE3.
Thoracic aortic aneurysm or dissection (GMS) v1.3 FOXE3 Zornitza Stark reviewed gene: FOXE3: Rating: AMBER; Mode of pathogenicity: None; Publications: 30071989; Phenotypes: Aortic aneurysm, familial thoracic 11, (susceptibility to) 617349; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Thoracic aortic aneurysm or dissection (GMS) v0.56 FOXE3 Ivone Leong Source Expert Review Green was added to FOXE3.
Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Thoracic aortic aneurysm or dissection (GMS) v0.55 FOXE3 Kate Thomson reviewed gene: FOXE3: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Thoracic aortic aneurysm or dissection (GMS) v0.44 FOXE3 Ivone Leong Phenotypes for gene: FOXE3 were changed from {Aortic aneurysm, familial thoracic 11, susceptibility to} to Aortic aneurysm, familial thoracic 11, (susceptibility to) 617349
Thoracic aortic aneurysm or dissection (GMS) v0.43 FOXE3 Ivone Leong Publications for gene: FOXE3 were set to
Thoracic aortic aneurysm or dissection (GMS) v0.35 FOXE3 Ivone Leong reviewed gene: FOXE3: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Thoracic aortic aneurysm or dissection (GMS) v0.30 FOXE3 James Eden reviewed gene: FOXE3: Rating: AMBER; Mode of pathogenicity: None; Publications: 26854927; Phenotypes: Aortic aneurysm, familial thoracic 11, (susceptibility to) 617349; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Thoracic aortic aneurysm or dissection (GMS) v0.30 FOXE3 Matthew Edwards reviewed gene: FOXE3: Rating: AMBER; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None
Thoracic aortic aneurysm or dissection (GMS) v0.0 FOXE3 Ellen McDonagh gene: FOXE3 was added
gene: FOXE3 was added to GMS FTAAD placeholder panel. Sources: Expert Review Amber,London South GLH,South West GLH
Mode of inheritance for gene: FOXE3 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: FOXE3 were set to {Aortic aneurysm, familial thoracic 11, susceptibility to}