Activity
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| COVID-19 research v1.62 | LY6E | Eleanor Williams commented on gene: LY6E: Preprint - https://doi.org/10.1101/2020.03.05.979260 - Pfaender et al - Mice lacking Ly6e in hematopoietic cells were highly susceptible to murine CoV infection. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| COVID-19 research v0.139 | LY6E |
Eleanor Williams gene: LY6E was added gene: LY6E was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: LY6E was set to Unknown Review for gene: LY6E was set to RED Added comment: Preprint - https://www.biorxiv.org/content/10.1101/2020.04.02.021469v1 - Zhao et al Found that human cell line C3A was more susceptible to human coronavirus HCoV-OC43 infection than HepG2. Ectopic expression of LY6E in HEK 293 cells inhibited the entry of HCoV-OC43. Overexpression of LY6E in C3A and A549 cells efficiently inhibited the infection of HCoV-OC43 and knockdown of LY6E expression in HepG2 significantly increased its susceptibility to HCoV-OC43 infection. LY6E also restricted the entry mediated by the envelope spike proteins of other human coronaviruses, including the currently pandemic SARS-CoV-2. Sources: Literature |
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