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COVID-19 research

Gene: LY6E

Red List (low evidence)

LY6E (lymphocyte antigen 6 family member E)
EnsemblGeneIds (GRCh38): ENSG00000160932
EnsemblGeneIds (GRCh37): ENSG00000160932
OMIM: 601384, Gene2Phenotype
LY6E is in 1 panel

1 review

Eleanor Williams (Genomics England Curator)

Red List (low evidence)

Preprint - - Pfaender et al - Mice lacking Ly6e in hematopoietic cells were highly susceptible to murine CoV infection.
Created: 27 Jul 2020, 1:24 p.m. | Last Modified: 27 Jul 2020, 1:24 p.m.
Panel Version: 1.62
Preprint - - Zhao et al
Found that human cell line C3A was more susceptible to human coronavirus HCoV-OC43 infection than HepG2. Ectopic expression of LY6E in HEK 293 cells inhibited the entry of HCoV-OC43. Overexpression of LY6E in C3A and A549 cells efficiently inhibited the infection of HCoV-OC43 and knockdown of LY6E expression in HepG2 significantly increased its susceptibility to HCoV-OC43 infection. LY6E also restricted the entry mediated by the envelope spike proteins of other human coronaviruses, including the currently pandemic SARS-CoV-2.
Sources: Literature
Created: 23 Apr 2020, 4:04 a.m.

Mode of inheritance


Mode of Inheritance
  • Literature
Clinvar variants
Variants in LY6E
Panels with this gene

History Filter Activity

23 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Eleanor Williams (Genomics England Curator)

gene: LY6E was added gene: LY6E was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: LY6E was set to Unknown Review for gene: LY6E was set to RED