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COVID-19 research

Gene: CYP2B6

Red List (low evidence)

CYP2B6 (cytochrome P450 family 2 subfamily B member 6)
EnsemblGeneIds (GRCh38): ENSG00000197408
EnsemblGeneIds (GRCh37): ENSG00000197408
OMIM: 123930, Gene2Phenotype
CYP2B6 is in 1 panel

1 review

Sarah Leigh (Genomics England Curator)

Red List (low evidence)

At least six CYP2B6 variants have been associated with poor metabolism of the antiviral - Efavirenz in different populations, resulting either a requirement for a lower dose of medication or central nervous system toxicity.
Created: 4 May 2020, 3:17 p.m. | Last Modified: 4 May 2020, 3:17 p.m.
Panel Version: 0.176

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

{Efavirenz central nervous system toxicity, susceptibility to} 614546; Efavirenz, poor metabolism of 614546



  • OMIM
Clinvar variants
Variants in CYP2B6
Panels with this gene

History Filter Activity

21 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Sarah Leigh (Genomics England Curator)

gene: CYP2B6 was added gene: CYP2B6 was added to Viral susceptibility. Sources: OMIM Mode of inheritance for gene: CYP2B6 was set to