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COVID-19 research

Gene: IL17A

Green List (high evidence)

IL17A (interleukin 17A)
EnsemblGeneIds (GRCh38): ENSG00000112115
EnsemblGeneIds (GRCh37): ENSG00000112115
OMIM: 603149, Gene2Phenotype
IL17A is in 3 panels

4 reviews

Abdelazeem Elhabyan (Arizona State University)

Green List (high evidence)

I agree that the level should be reviewed for being increased to Green especially the association of SNPs with H1N1 (influenza A) and influenza B.


Association with CNVs with pathology has been confirmed but the disease state was not revealed in any of the patients
https://www.ncbi.nlm.nih.gov/clinvar?LinkName=gene_clinvar&from_uid=3605
Created: 7 Apr 2020, 11:36 a.m. | Last Modified: 7 Apr 2020, 11:36 a.m.
Panel Version: 0.59

Ivone Leong (Genomics England Curator)

Comment on list classification: Promoted from Amber to Green as there is enough evidence in the literature to support this.
Created: 8 Apr 2020, 9:27 a.m. | Last Modified: 8 Apr 2020, 9:27 a.m.
Panel Version: 0.66
Comment on list classification: Promoted from Red to Amber. There appears to be enough evidence for this gene to be promoted Green; however, will wait for expert review before promoting to Green.
Created: 7 Apr 2020, 9:10 a.m. | Last Modified: 7 Apr 2020, 9:10 a.m.
Panel Version: 0.58
IL-17A is important for protection from bacterial, fungal and viral infections in the mucosal tracts. Aberrant expression or over expression of IL-17 causes a range of outcomes: asthma, lung inflammation and lung fibrosis (PMID: 28860146).

PMID: 31196204 is a case-control study that looked at 50 H1N1 (influenza A), 30 influenza B and 96 influenza-like illness (ILI) confirmed Iranian cases. The rs2275913 SNP in IL-17 increased the risk of H1N1 infection (P=0.008). PMID: 27155288 also found rs2275913 is asosicated with risk of infection by H3N2 (P < 0.05, OR = 2.08-2.94).

PMID: 27890033 investigated patients who had acute brochiolitis (from mild to severe respiratory failure) in Brazil. The study found that IL-17 rs2275913 SNP showed significant association with acute brochiolitis severity (P<0.001).

PMID: 21703407 showed that mice infected with respiratory syncytial virus (RSV) and treated with anti-IL-17 had reduced inflammation and decreased viral load compared to control mice. Blocking IL-17 during infection significantly increased RSV specific CD8 T cells, and factors associated with CD8 T cells cytotoxicity were significantly upregulated.

PMID: 29530464 showed that IL-17A expression may be involved with the development and severity of viral myocarditis (VMC). The SNP rs2275913 might influence on susceptibility to VMC.
Created: 7 Apr 2020, 8:45 a.m. | Last Modified: 7 Apr 2020, 8:45 a.m.
Panel Version: 0.54

Mode of inheritance
Unknown

Publications

Sophie Hambleton (Newcastle University)

Red List (low evidence)

Variants in this gene not associated with Mendelian disease in the published literature to date
Created: 20 Jun 2018, 7:17 p.m.

Louise Daugherty (Genomics England Curator)

I don't know

Comment on list classification: Changed from Amber to Red, no evident link to mendelian immunodeficiency. red review from external expert review.
Created: 21 Jun 2018, 1:29 p.m.
This gene was absent from the original PanelApp PID panel dataset (review April 2018). However it was listed in external expert immunodeficiency diagnostic gene list(s) GOSH or GRID. In this combined PID panel, this gene has been rated as AMBER and needs further curational review to assess pertinence prior to v1.
Created: 20 Apr 2018, 12:25 p.m.
Original metadata supplied by GRID. GRID Gene Symbol HGNC PanelApp check: IL17A, GRID_Gene_Symbol: IL17A, GRID_Transcript_ENS_Community submitted: ENST00000340057, GRID_Transcript_RefSeq: NM_002190.2, GRID_Transcript_ENS_used_on_Production: ENST00000340057
Created: 17 Apr 2018, 12:12 p.m.

Details

Mode of Inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Sources
  • Expert Review Green
Phenotypes
  • Arthritis
  • Immunodeficiency 5
  • Susceptibility to influenza
OMIM
603149
Clinvar variants
Variants in IL17A
Penetrance
None
Publications
Panels with this gene

History Filter Activity

8 Apr 2020, Gel status: 3

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: il17a has been classified as Green List (High Evidence).

7 Apr 2020, Gel status: 2

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: il17a has been classified as Amber List (Moderate Evidence).

7 Apr 2020, Gel status: 1

Set Phenotypes

Ivone Leong (Genomics England Curator)

Phenotypes for gene: IL17A were changed from Arthritis; Immunodeficiency 5 to Arthritis; Immunodeficiency 5; Susceptibility to influenza

7 Apr 2020, Gel status: 1

Set mode of inheritance

Ivone Leong (Genomics England Curator)

Mode of inheritance for gene: IL17A was changed from Unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal

7 Apr 2020, Gel status: 1

Set publications

Ivone Leong (Genomics England Curator)

Publications for gene: IL17A were set to

1 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: IL17A was added gene: IL17A was added to Viral susceptibility. Sources: Expert Review Red,GRID V2.0 Mode of inheritance for gene: IL17A was set to Unknown Phenotypes for gene: IL17A were set to Arthritis; Immunodeficiency 5