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COVID-19 research

Gene: IL7

Amber List (moderate evidence)

IL7 (interleukin 7)
EnsemblGeneIds (GRCh38): ENSG00000104432
EnsemblGeneIds (GRCh37): ENSG00000104432
OMIM: 146660, Gene2Phenotype
IL7 is in 2 panels

3 reviews

Alison Coffey (Illumina Clinical Services Laboratory, Illumina Inc.)

I don't know

Mode of inheritance
Unknown

Publications

Sarah Leigh (Genomics England Curator)

IL7 was identified through an OMIM search for potential viral susceptibility genes. Initial triage by Illumina (Alison Coffey and team) was given a Tier 1 grouping (clear GDA/viral susceptibility). Illumina review: PMID 25981006 – Horev et al. (2015) reported three cases from one consanguineous Arab family characterized by severe CD41T-cell lymphopenia, generalized verrucosis due to HPV infections, predisposition to opportunistic C. neoformans meningitis, and recurrent squamous cell carcinomas of the skin in sun-exposed areas. Whole exome sequencing analysis of one case (patient 3) identified a homozygous variant in the IL 7 gene, c.205A>T ( p.Arg69Ter). PMID: 31900472 Kosumi et al. (2020) reported two generalized verrucosis (GV) patients homozygous for a novel mutation in the start codon of IL7. IL-7 deficiency was not accompanied CD4 T lymphocytopenia, circulating CD4 T-cells were not depleted in one of the patients, suggesting a GV pathogenesis other than poor T-cell development.
Created: 11 Jun 2020, 6:10 p.m. | Last Modified: 12 Jun 2020, 10:43 a.m.
Panel Version: 1.35

Rebecca Foulger (Genomics England curator)

Identified through an OMIM search for potential viral susceptibility genes, and subsequently triaged/reviewed by Illumina curation team.
Created: 2 Jun 2020, 1:52 p.m. | Last Modified: 2 Jun 2020, 1:52 p.m.
Panel Version: 1.1

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
Phenotypes
  • {?Epidermodysplasia verruciformis, susceptibility to, 5}, 618309
OMIM
146660
Clinvar variants
Variants in IL7
Penetrance
None
Publications
Panels with this gene

History Filter Activity

12 Jun 2020, Gel status: 2

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: IL7 were set to 25981006

2 Jun 2020, Gel status: 2

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Rebecca Foulger (Genomics England curator)

gene: IL7 was added gene: IL7 was added to COVID-19 research. Sources: OMIM,Expert list,Expert Review Amber Mode of inheritance for gene: IL7 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: IL7 were set to 25981006 Phenotypes for gene: IL7 were set to {?Epidermodysplasia verruciformis, susceptibility to, 5}, 618309