Genes in panel
STRs in panel
Prev Next

COVID-19 research

Gene: TLR5

Red List (low evidence)

TLR5 (toll like receptor 5)
EnsemblGeneIds (GRCh38): ENSG00000187554
EnsemblGeneIds (GRCh37): ENSG00000187554
OMIM: 603031, Gene2Phenotype
TLR5 is in 1 panel

1 review

Sarah Leigh (Genomics England Curator)

TLR5 was identified through an OMIM search for potential viral susceptibility genes. Based on initial triage by Illumina (Tier 5 grouping).
The transmembrane protein TLR5 is a component of the immune system that is highly expressed in intestinal mucosa and recognizes bacterial flagellin (PMID 20203013)(reviewed by Alison Coffey and team, Illumina).
PMID 25395539 reports that mice treated with bacterial flagellin prevented rotavirus (RV) infection and cured chronically RV-infections. This process required the flagellin receptors Tlr5 and Nlrc4. Flagellin-induced activation of Tlr5 on dendritic cells elicited production of the cytokine Il22, resulting in a protective gene expression program in intestinal epithelial cells. Administration of Il22 to mice reproduced the capacity of flagellin to prevent or cure RV. It was proposed that activation of innate immunity with flagellin, via Tlr5 inducing IL22 could be useful in preventing or curing viral infections.
Created: 28 May 2020, 4:33 p.m. | Last Modified: 28 May 2020, 5:46 p.m.
Panel Version: 0.364
Comment on list classification: Not associated with phenotype in OMIM or in Gen2Phen. However, there is evidence that this gene is associated with the immune response to viral infection (PMID 25395539).
Created: 28 May 2020, 4:12 p.m. | Last Modified: 28 May 2020, 4:12 p.m.
Panel Version: 0.354



Mode of Inheritance
  • Expert Review Red
  • OMIM
  • {Legionnaire disease, susceptibility to} 608556
Clinvar variants
Variants in TLR5
Panels with this gene

History Filter Activity

28 May 2020, Gel status: 1

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: TLR5 were set to

28 May 2020, Gel status: 1

Entity classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

Gene: tlr5 has been classified as Red List (Low Evidence).

28 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Sarah Leigh (Genomics England Curator)

gene: TLR5 was added gene: TLR5 was added to COVID-19 research. Sources: OMIM Mode of inheritance for gene: TLR5 was set to Unknown Phenotypes for gene: TLR5 were set to {Legionnaire disease, susceptibility to} 608556