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COVID-19 research

Gene: BST2

Red List (low evidence)

BST2 (bone marrow stromal cell antigen 2)
EnsemblGeneIds (GRCh38): ENSG00000130303
EnsemblGeneIds (GRCh37): ENSG00000130303
OMIM: 600534, Gene2Phenotype
BST2 is in 1 panel

1 review

Rebecca Foulger (Genomics England curator)

Comment on list classification: Added to panel as a Red gene: present in latest release of UniProt COVID portal. Plays a role in tethering viruses to the host cell to block viral release. Recent research (PMID:31199522) shows interaction with SARS-CoV spike protein, which inhibits BST2 function and allows viral release.
Created: 12 May 2020, 10:25 a.m. | Last Modified: 12 May 2020, 10:25 a.m.
Panel Version: 0.216
PMID:31199522. Wang et al., 2019 show that SARS-CoV spike (S) glycoprotein antagonises the BST2 tethering of SARS-CoV via BST2 downregulation. The authors show colocalization BST2 and SARS-CoV S protein.
Created: 12 May 2020, 10:24 a.m. | Last Modified: 12 May 2020, 10:24 a.m.
Panel Version: 0.215
BST2 is present in the UniProt COVID portal (11th May 2020 Release): BST2 is an IFN-induced antiviral host restriction factor which physically blocks the release of viruses by directly tethering nascent virions to the membranes of infected cells.
Sources: Literature, Other
Created: 12 May 2020, 10:24 a.m.

Mode of inheritance



Mode of Inheritance
  • Expert Review Red
  • Other
  • Literature
Clinvar variants
Variants in BST2
Panels with this gene

History Filter Activity

12 May 2020, Gel status: 1

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: bst2 has been classified as Red List (Low Evidence).

12 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications

Rebecca Foulger (Genomics England curator)

gene: BST2 was added gene: BST2 was added to Viral susceptibility. Sources: Literature,Other Mode of inheritance for gene: BST2 was set to Unknown Publications for gene: BST2 were set to 31199522