Genes in panel
STRs in panel
Prev Next

COVID-19 research

Gene: BST2

Red List (low evidence)

BST2 (bone marrow stromal cell antigen 2)
EnsemblGeneIds (GRCh38): ENSG00000130303
EnsemblGeneIds (GRCh37): ENSG00000130303
OMIM: 600534, Gene2Phenotype
BST2 is in 1 panel

1 review

Rebecca Foulger (Genomics England curator)

Comment on list classification: Added to panel as a Red gene: present in latest release of UniProt COVID portal. Plays a role in tethering viruses to the host cell to block viral release. Recent research (PMID:31199522) shows interaction with SARS-CoV spike protein, which inhibits BST2 function and allows viral release.
Created: 12 May 2020, 10:25 a.m. | Last Modified: 12 May 2020, 10:25 a.m.
Panel Version: 0.216
PMID:31199522. Wang et al., 2019 show that SARS-CoV spike (S) glycoprotein antagonises the BST2 tethering of SARS-CoV via BST2 downregulation. The authors show colocalization BST2 and SARS-CoV S protein.
Created: 12 May 2020, 10:24 a.m. | Last Modified: 12 May 2020, 10:24 a.m.
Panel Version: 0.215
BST2 is present in the UniProt COVID portal (11th May 2020 Release): https://covid-19.uniprot.org/uniprotkb/Q10589. BST2 is an IFN-induced antiviral host restriction factor which physically blocks the release of viruses by directly tethering nascent virions to the membranes of infected cells.
Sources: Literature, Other
Created: 12 May 2020, 10:24 a.m.

Mode of inheritance
Unknown

Publications

Details

Mode of Inheritance
Unknown
Sources
OMIM
600534
Clinvar variants
Variants in BST2
Penetrance
None
Publications
Panels with this gene

History Filter Activity

12 May 2020, Gel status: 1

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: bst2 has been classified as Red List (Low Evidence).

12 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications

Rebecca Foulger (Genomics England curator)

gene: BST2 was added gene: BST2 was added to Viral susceptibility. Sources: Literature,Other Mode of inheritance for gene: BST2 was set to Unknown Publications for gene: BST2 were set to 31199522