COVID-19 research
Gene: IRF4
Single kindred, incomplete penetrance; relatively weak evidence of its causative nature re Whipple's disease but undoubtedly encodes an immunologically important transcription factorCreated: 1 May 2020, 11:03 a.m. | Last Modified: 1 May 2020, 11:03 a.m.
Panel Version: 0.171
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Whipple's disease
IUIS: categorised under the Other inborn errors of immunity related to leukocytes section. Inheritance: AD. Affects L+M cells, IRF4 is a pleiotropic transcription factor. Associated features: Whipples disease.Created: 15 Apr 2020, 12:09 p.m. | Last Modified: 15 Apr 2020, 12:09 p.m.
Panel Version: 0.103
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Defects in intrinsic and innate immunity; inborn errors of immunity related to leukocytes; IRF4 haploinsufficiency
Publications
Mode of inheritance for gene: IRF4 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Publications for gene: IRF4 were set to
gene: IRF4 was added gene: IRF4 was added to Viral susceptibility. Sources: Expert Review Green,IUIS Classification December 2019 Mode of inheritance for gene: IRF4 was set to Phenotypes for gene: IRF4 were set to Defects in intrinsic and innate immunity; IRF4 haploinsufficiency; inborn errors of immunity related to leukocytes