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COVID-19 research

Gene: IL22

Red List (low evidence)

IL22 (interleukin 22)
EnsemblGeneIds (GRCh38): ENSG00000127318
EnsemblGeneIds (GRCh37): ENSG00000127318
OMIM: 605330, Gene2Phenotype
IL22 is in 5 panels

3 reviews

Rebecca Foulger (Genomics England curator)

Comment on list classification: Kept rating as Red: mouse model in PMID:22952908 suggests IL22 deficiency promotes resistance. IL22 administration in PMID:25395539 report possible viral protection.
Created: 23 Apr 2020, 3:26 p.m. | Last Modified: 23 Apr 2020, 3:26 p.m.
Panel Version: 0.144
Mouse model in PMID:22952908: Il22(-/-) mice were more resistant to lethal West Nile virus (WNV) encephalitis.
Created: 23 Apr 2020, 3:24 p.m. | Last Modified: 23 Apr 2020, 3:24 p.m.
Panel Version: 0.143
PMID:25395539 (Zhang et al 2014) report that IL-18 and IL-22 administration to mice offered protection against a broad range of RV inoculation, and may offer broad antiviral therapeutic potential.
Created: 20 Apr 2020, 8:38 p.m. | Last Modified: 20 Apr 2020, 8:38 p.m.
Panel Version: 0.118

Sophie Hambleton (Newcastle University)

Red List (low evidence)

No association with human disease identified yet
Created: 20 Jun 2018, 7:27 p.m.

Louise Daugherty (Genomics England Curator)

I don't know

Comment on list classification: Changed from Amber to Red, no published cases of immunodeficiency to date. Red review from external expert review. Referred back to GRID for evidences.
Created: 21 Jun 2018, 3:04 p.m.
This gene was absent from the original PanelApp PID panel dataset (review April 2018). However it was listed in external expert immunodeficiency diagnostic gene list(s) GOSH or GRID. In this combined PID panel, this gene has been rated as AMBER and needs further curational review to assess pertinence prior to v1.
Created: 20 Apr 2018, 12:25 p.m.
Original metadata supplied by GRID. GRID Gene Symbol HGNC PanelApp check: IL22, GRID_Gene_Symbol: IL22, GRID_Transcript_ENS_Community submitted: ENST00000538666, GRID_Transcript_RefSeq: NM_020525, GRID_Transcript_ENS_used_on_Production: ENST00000538666
Created: 17 Apr 2018, 12:12 p.m.

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
Phenotypes
  • AutoAb Chronic Mucocutaneous Candidiasis
OMIM
605330
Clinvar variants
Variants in IL22
Penetrance
None
Publications
Panels with this gene

History Filter Activity

23 Apr 2020, Gel status: 1

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: il22 has been classified as Red List (Low Evidence).

20 Apr 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: IL22 were set to 25395539

20 Apr 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: IL22 were set to

1 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: IL22 was added gene: IL22 was added to Viral susceptibility. Sources: Expert Review Red,GRID V2.0 Mode of inheritance for gene: IL22 was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: IL22 were set to AutoAb Chronic Mucocutaneous Candidiasis