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COVID-19 research

Gene: CCL2

Green List (high evidence)

CCL2 (C-C motif chemokine ligand 2)
EnsemblGeneIds (GRCh38): ENSG00000108691
EnsemblGeneIds (GRCh37): ENSG00000108691
OMIM: 158105, Gene2Phenotype
CCL2 is in 5 panels

3 reviews

Sophie Hambleton (Newcastle University)

Green List (high evidence)

Interesting candidate gene, no evidence for Mendelian behaviour
Created: 27 Apr 2020, 11:56 a.m. | Last Modified: 27 Apr 2020, 11:56 a.m.
Panel Version: 0.163

Mode of inheritance
Unknown

Rebecca Foulger (Genomics England curator)

Comment on list classification: Updated rating of CCL2 from Red to Green. 3 publications supporting an association between CCL2 SNP(s) and viral infections including HIV, Japanese encephalitis and SARs. Additional evidence that CCL2 levels are raised after viral infection.
Created: 14 Apr 2020, 2:13 p.m. | Last Modified: 14 Apr 2020, 2:13 p.m.
Panel Version: 0.88
PMID:29057937 (Chowdhury and Khan, 2017) report that SNPs of CCL2 (rs1024611G) and its receptor CCR2 (rs1799864A) significantly associated with Japanese encephalitis (JE) which may serve as possible genetic predisposing factor. JE is one of the major viral encephalitis in Asia and parts of Western Pacific.
Created: 14 Apr 2020, 2:11 p.m. | Last Modified: 14 Apr 2020, 2:11 p.m.
Panel Version: 0.85
PMID:27260136 (Kim et al., 2016) report that CCL2 ablation highly increased susceptibility to Japanese encephalitis, indicating that CCL2 plays an essential role in conferring protection against JE caused by JE virus (JEV) infection. They also note a surprising opposite effect for ablation of the CCR2 (the corresponding receptor).
Created: 6 Apr 2020, 10:41 a.m. | Last Modified: 6 Apr 2020, 10:41 a.m.
Panel Version: 0.47
PMID:24788844 (Han et al., 2014) studied 36 Chines patients and report that the CCL2-2510G allele is associated with susceptibility to EV71 encephalitis in Chinese patients.
Created: 6 Apr 2020, 10:33 a.m. | Last Modified: 6 Apr 2020, 10:33 a.m.
Panel Version: 0.46
PMID:16916890 (Ansari et al.) report increased CCL2 levels in HIV-1 patients, and suggest inhibition of CCL2 production could provide a therapeutic intervention in HIV infection.
Created: 6 Apr 2020, 10:24 a.m. | Last Modified: 6 Apr 2020, 10:24 a.m.
Panel Version: 0.45
PMID:26687605 (Covino et al., 2016) report that CCL2 is involve in the pathogenesis of infections with either bacterial or viral pathogens, such as human rhinovirus (HRV), respiratory syncytial virus (RSV), human cytomegalovirus (HCMV), simian human immunodeficiency virus (SHIV), and HIV. CCL2 is unique among the chemokines in that mostly enhancing effects on viral replication and pathogenesis have been reported. Either HIV infection itself or exposure to viral products can induce the expression of CCL2 (and its receptor CCR2).
Created: 6 Apr 2020, 10:23 a.m. | Last Modified: 6 Apr 2020, 10:23 a.m.
Panel Version: 0.44

Ellen McDonagh (Genomics England Curator)

PMID: 25818534 reports that the CCL2 G-2518A and MBL codon 54 variants have a significantly cumulative effect on increased risk of SARS-CoV infection.
Sources: Literature
Created: 30 Mar 2020, 3:51 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection; Susceptibility to SARS-CoV

Publications

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
Phenotypes
  • {HIV-1, resistance to}, 609423
  • Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection
  • Susceptibility to SARS-CoV
  • Susceptibility to viral Japanese encephalitis
OMIM
158105
Clinvar variants
Variants in CCL2
Penetrance
None
Publications
Panels with this gene

History Filter Activity

14 Apr 2020, Gel status: 3

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: ccl2 has been classified as Green List (High Evidence).

14 Apr 2020, Gel status: 1

Set Phenotypes

Rebecca Foulger (Genomics England curator)

Phenotypes for gene: CCL2 were changed from {HIV-1, resistance to}, 609423; Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection; Susceptibility to SARS-CoV to {HIV-1, resistance to}, 609423; Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection; Susceptibility to SARS-CoV; Susceptibility to viral Japanese encephalitis

14 Apr 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: CCL2 were set to 25818534; 26687605; 16916890; 24788844; 27260136

6 Apr 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: CCL2 were set to 25818534; 26687605; 16916890; 24788844

6 Apr 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: CCL2 were set to 25818534; 26687605; 16916890

6 Apr 2020, Gel status: 1

Set Phenotypes

Rebecca Foulger (Genomics England curator)

Phenotypes for gene: CCL2 were changed from Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection; Susceptibility to SARS-CoV to {HIV-1, resistance to}, 609423; Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection; Susceptibility to SARS-CoV

6 Apr 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: CCL2 were set to 25818534

30 Mar 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: CCL2 was added gene: CCL2 was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: CCL2 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: CCL2 were set to 25818534 Phenotypes for gene: CCL2 were set to Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection; Susceptibility to SARS-CoV